The blood‐brain barrier (BBB), as a crucial gate of brain‐blood molecular exchange, is
involved in the pathogenesis of multiple neurological diseases. Oxidative stress is caused …

Mitochondria are the main organelles that produce adenosine 5′‐triphosphate (ATP) and
reactive oxygen species (ROS) in eukaryotic cells and meanwhile susceptible to oxidative …

Cardiovascular disease (CVD) affects one in three adults and remains the leading cause of
death in America. Advancing age is a major risk factor for CVD. Recent plateaus in CVD …

Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

The majority of traumatic brain injuries (TBIs), approximately 90%, are classified as mild
(mTBIs). Globally, an estimated 4 million injuries occur each year from concussions or …

The existing treatments for ischemic stroke cannot meet the clinical needs so far. Quercetin
(QT) is an effective apoptosis inhibitor and antioxidant flavonoid, but its water solubility is …

Due to the pivotal role of mitochondria in the generation of adenosine triphosphate (ATP)
and the regulation of cellular homeostasis, mitochondrial dysfunction may exert a profound …

Cognitive impairment and dementias during aging such as Alzheimer's disease are linked to
functional decline and structural alterations of the brain microvasculature. Although …

Oxidative stress imposes a substantial cellular burden on the brain and contributes to
diverse neurodegenerative diseases. Various antioxidant signaling pathways have been …

Background Dilated cardiomyopathy with ataxia syndrome (DCMA) is an understudied
autosomal recessive disease caused by loss-of-function mutations in the poorly …