Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …

The primary adrenal cortical steroid hormones, aldosterone, and the glucocorticoids cortisol
and corticosterone, act through the structurally similar mineralocorticoid (MR) and …

The Western-style diet is characterized by its highly processed and refined foods and high
contents of sugars, salt, and fat and protein from red meat. It has been recognized as the …

Age-related diseases for which there are no effective treatments include cardiovascular
diseases; neurodegenerative diseases such as Alzheimer's disease; eye disorders such as …

Breast cancer (BC) remains the primary cause of death from cancer among women
worldwide. Cholesterol-5, 6-epoxide (5, 6-EC) metabolism is deregulated in BC but the …

Tibetan sheep have lived on the Tibetan Plateau for thousands of years; however, the
process and consequences of adaptation to this extreme environment have not been …

11β-Hydroxysteroid dehydrogenase type 1 (11HSD1) regenerates cortisol from cortisone
within adipose tissue and liver. 11HSD1 inhibitors may enhance insulin sensitivity in type 2 …

In the last decade significant progress has been made in the understanding of
mineralocorticoid receptor (MR) function and its implications for physiology and disease …

The metabolic abnormalities found associated with high blood glucocorticoid levels (eg rare
Cushing's syndrome) include insulin-resistance, visceral obesity, hypertension …

The local generation of active glucocorticoid by NADPH-dependent, 11β-hydroxysteroid
dehydrogenase type 1 (11β-HSD1) oxoreductase activity, has emerged as an important …