Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

Dysregulation of the epigenome drives aberrant transcriptional programmes that promote
cancer onset and progression. Although defective gene regulation often affects oncogenic …

Epigenetic dysregulation is a defining feature of tumorigenesis that is implicated in immune
escape,. Here, to identify factors that modulate the immune sensitivity of cancer cells, we …

Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction
pathways that regulate all aspects of life and are frequently altered in disease. Here, we …

Vitamins B9 (folate) and B12 are essential water-soluble vitamins that play a crucial role in
the maintenance of one-carbon metabolism: a set of interconnected biochemical pathways …

Bladder cancer (BCa), characterized by high invasion, metastasis, recurrence, and
chemoresistance, is one of the most prevalent urologic malignant tumors. Recent studies …

During tumor progression, cancer cells come into contact with various non-tumor cell types,
but it is unclear how tumors adapt to these new environments. Here, we integrate spatially …

Advanced, metastatic melanomas frequently grow in subcutaneous tissues and portend a
poor prognosis. Though subcutaneous tissues are largely composed of adipocytes, the …

In precision oncology, two major strategies are being pursued for predicting clinically
relevant tumour behaviours, such as treatment response and emergence of drug resistance …

One-carbon metabolism involving the folate and methionine cycles integrates nutritional
status from amino acids, glucose and vitamins, and generates diverse outputs, such as the …