Pathogenesis, Molecular Genetics, and Genomics of Mycobacterium avium subsp. paratuberculosis, the Etiologic Agent of Johne's Disease

G Rathnaiah, DK Zinniel, JP Bannantine… - Frontiers in veterinary …, 2017 - frontiersin.org
Mycobacterium avium subsp. paratuberculosis (MAP) is the etiologic agent of Johne's
disease in ruminants causing chronic diarrhea, malnutrition, and muscular wasting …

Culture of Mycobacterium avium subsp. paratuberculosis: challenges, limitations and future prospects

H Dane, LD Stewart, IR Grant - Journal of Applied Microbiology, 2023 - academic.oup.com
Mycobacterium avium subsp. paratuberculosis (MAP) causes paratuberculosis (Johne's
disease) in ruminants and is suspected to be involved in the development of Crohn's …

Regionally Distinct Immune and Metabolic Transcriptional Responses in the Bovine Small Intestine and Draining Lymph Nodes During a Subclinical Mycobacterium avium …

EM Ibeagha-Awemu, N Bissonnette, DN Do… - Frontiers in …, 2021 - frontiersin.org
Mycobacterium avium subsp. paratuberculosis (MAP) is the causative infectious agent of
Johne's disease (JD), an incurable granulomatous enteritis affecting domestic livestock and …

No holes barred: invasion of the intestinal mucosa by Mycobacterium avium subsp. paratuberculosis

JP Bannantine, LE Bermudez - Infection and immunity, 2013 - Am Soc Microbiol
The infection biology of Mycobacterium avium subsp. paratuberculosis has recently
crystallized, with added details surrounding intestinal invasion. The involvement of pathogen …

Iron acquisition in Mycobacterium avium subsp. paratuberculosis

J Wang, J Moolji, A Dufort, A Staffa… - Journal of …, 2016 - Am Soc Microbiol
Mycobacterium avium subsp. paratuberculosis is a host-adapted pathogen that evolved from
the environmental bacterium M. avium subsp. hominissuis through gene loss and gene …

Delineating transcriptional crosstalk between Mycobacterium avium subsp. paratuberculosis and human THP-1 cells at the early stage of infection via dual RNA-seq …

HT Park, SM Lee, S Ko, S Kim, HE Park, MK Shin… - Veterinary …, 2022 - Springer
Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of Johne's
disease, a chronic debilitating disease in ruminants. To control this disease, it is crucial to …

Host-Mycobacterium avium subsp. paratuberculosis interactome reveals a novel iron assimilation mechanism linked to nitric oxide stress during early infection

EA Lamont, WW Xu, S Sreevatsan - Bmc Genomics, 2013 - Springer
Background The initial interaction between host cell and pathogen sets the stage for the
ensuing infection and ultimately determine the course of disease. However, there is limited …

The Fur-like regulatory protein MAP3773c modulates key metabolic pathways in Mycobacterium avium subsp. paratuberculosis under in-vitro iron starvation

S Thapa, G Rathnaiah, DK Zinniel, RG Barletta… - Scientific Reports, 2024 - nature.com
Johne's disease (JD) is a chronic enteric infection of dairy cattle worldwide. Mycobacterium
avium subsp. paratuberculosis (MAP), the causative agent of JD, is fastidious often requiring …

Key role for the alternative sigma factor, SigH, in the intracellular life of Mycobacterium avium subsp. paratuberculosis during macrophage stress

P Ghosh, C Wu, AM Talaat - Infection and immunity, 2013 - Am Soc Microbiol
Mycobacterium avium subsp. paratuberculosis causes Johne's disease, an enteric infection
in cattle and other ruminants, greatly afflicting the dairy industry worldwide. Once inside the …

Modeling Paratuberculosis in Laboratory Animals, Cells, or Tissues: A Focus on Their Applications for Pathogenesis, Diagnosis, Vaccines, and Therapy Studies

A Jolly, B Fernández, SL Mundo, N Elguezabal - Animals, 2023 - mdpi.com
Simple Summary Paratuberculosis is a chronic infectious disease that affects a wide variety
of domestic and wild animals. It is considered one of the diseases with the highest economic …