Cisplatin binding to proteins: A structural perspective
The interactions of clinically established anticancer Pt-based drugs with proteins play crucial
roles in Pt cellular uptake and biodistribution, as well as in determining side effects and …
roles in Pt cellular uptake and biodistribution, as well as in determining side effects and …
Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs
Mass spectrometry (MS) has emerged as an important tool for studying anticancer
metallodrugs in complex biological samples and for characterising their interactions with …
metallodrugs in complex biological samples and for characterising their interactions with …
An integrated native mass spectrometry and top-down proteomics method that connects sequence to structure and function of macromolecular complexes
Mass spectrometry (MS) has become a crucial technique for the analysis of protein
complexes. Native MS has traditionally examined protein subunit arrangements, while …
complexes. Native MS has traditionally examined protein subunit arrangements, while …
Interactions of anticancer Pt compounds with proteins: an overlooked topic in medicinal inorganic chemistry?
A critical discussion is presented about the possible role of Pt–protein interactions in the
mechanisms of action of platinum anticancer compounds. Although, since 40 years from its …
mechanisms of action of platinum anticancer compounds. Although, since 40 years from its …
Radical solutions: Principles and application of electron‐based dissociation in mass spectrometry‐based analysis of protein structure
In recent years, electron capture (ECD) and electron transfer dissociation (ETD) have
emerged as two of the most useful methods in mass spectrometry‐based protein analysis …
emerged as two of the most useful methods in mass spectrometry‐based protein analysis …
Mass spectrometry as a powerful tool to study therapeutic metallodrugs speciation mechanisms: Current frontiers and perspectives
M Wenzel, A Casini - Coordination Chemistry Reviews, 2017 - Elsevier
Metal-based compounds form a promising class of therapeutic agents, whose mechanisms
of action still need to be elucidated, and that are in general prone to undergo extensive …
of action still need to be elucidated, and that are in general prone to undergo extensive …
Applying mass spectrometry to study non‐covalent biomolecule complexes
F Chen, B Gülbakan, S Weidmann… - Mass spectrometry …, 2016 - Wiley Online Library
Non‐covalent interactions are essential for the structural organization of biomacromolecules
and play an important role in molecular recognition processes, such as the interactions …
and play an important role in molecular recognition processes, such as the interactions …
Metal ion binding to the amyloid β monomer studied by native top-down FTICR mass spectrometry
Native top-down mass spectrometry is a fast, robust biophysical technique that can provide
molecular-scale information on the interaction between proteins or peptides and ligands …
molecular-scale information on the interaction between proteins or peptides and ligands …
Pt-based drugs: the spotlight will be on proteins
O Pinato, C Musetti, C Sissi - Metallomics, 2014 - academic.oup.com
Platinum-complexes represent some of the most successful groups of clinically used
anticancer drugs. Their mechanism of action relies on the formation of stable DNA adducts …
anticancer drugs. Their mechanism of action relies on the formation of stable DNA adducts …
Revealing ligand binding sites and quantifying subunit variants of noncovalent protein complexes in a single native top-down FTICR MS experiment
“Native” mass spectrometry (MS) has been proven to be increasingly useful for structural
biology studies of macromolecular assemblies. Using horse liver alcohol dehydrogenase …
biology studies of macromolecular assemblies. Using horse liver alcohol dehydrogenase …