From actin waves to mechanism and back: how theory aids biological understanding
Actin dynamics in cell motility, division, and phagocytosis is regulated by complex factors
with multiple feedback loops, often leading to emergent dynamic patterns in the form of …
with multiple feedback loops, often leading to emergent dynamic patterns in the form of …
Mechanisms of cell polarization
Cell polarization is a key step in the migration, development, and organization of eukaryotic
cells, both at the single cell and multicellular level. Research on the mechanisms that give …
cells, both at the single cell and multicellular level. Research on the mechanisms that give …
Mechanical cell-matrix feedback explains pairwise and collective endothelial cell behavior in vitro
In vitro cultures of endothelial cells are a widely used model system of the collective
behavior of endothelial cells during vasculogenesis and angiogenesis. When seeded in an …
behavior of endothelial cells during vasculogenesis and angiogenesis. When seeded in an …
Polarity mechanisms such as contact inhibition of locomotion regulate persistent rotational motion of mammalian cells on micropatterns
Pairs of endothelial cells on adhesive micropatterns rotate persistently, but pairs of
fibroblasts do not; coherent rotation is present in normal mammary acini and kidney cells but …
fibroblasts do not; coherent rotation is present in normal mammary acini and kidney cells but …
Emergence and persistence of collective cell migration on small circular micropatterns
FJ Segerer, F Thüroff, A Piera Alberola, E Frey… - Physical Review Letters, 2015 - APS
The spontaneous formation of vortices is a hallmark of collective cellular activity. Here, we
study the onset and persistence of coherent angular motion as a function of the number of …
study the onset and persistence of coherent angular motion as a function of the number of …
Viscoelasticity, like forces, plays a role in mechanotransduction
CT Mierke - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Viscoelasticity and its alteration in time and space has turned out to act as a key element in
fundamental biological processes in living systems, such as morphogenesis and motility …
fundamental biological processes in living systems, such as morphogenesis and motility …
From energy to cellular forces in the Cellular Potts Model: An algorithmic approach
EG Rens, L Edelstein-Keshet - PLoS computational biology, 2019 - journals.plos.org
Single and collective cell dynamics, cell shape changes, and cell migration can be
conveniently represented by the Cellular Potts Model, a computational platform based on …
conveniently represented by the Cellular Potts Model, a computational platform based on …
Confinement and substrate topography control cell migration in a 3D computational model
Cell movement in vivo is typically characterized by strong confinement and heterogeneous,
three-dimensional environments. Such external constraints on cell motility are known to play …
three-dimensional environments. Such external constraints on cell motility are known to play …
Bridging from single to collective cell migration: A review of models and links to experiments
Mathematical and computational models can assist in gaining an understanding of cell
behavior at many levels of organization. Here, we review models in the literature that focus …
behavior at many levels of organization. Here, we review models in the literature that focus …
Phase-field modeling of individual and collective cell migration
Cell motion is crucial in human health and development. Cells may migrate individually or in
highly coordinated groups. Cell motion results from complex intra-and extra-cellular …
highly coordinated groups. Cell motion results from complex intra-and extra-cellular …