Abstract Polo-like kinase 4 (PLK4), a highly conserved serine/threonine kinase, masterfully
regulates centriole duplication in a spatiotemporal manner to ensure the fidelity of …

The tumor-adipose microenvironment (TAME) is a universal microecosystem, that is
characterized by the dysfunction of lipid metabolism, such as excessive free fatty acids …

Centrosomes are best known as the microtubule organizing centers (MTOCs) of eukaryotic
cells. In addition to their classic role in chromosome segregation, centrosomes play diverse …

Protein tyrosine kinase-7 (PTK7) has been reported as a vital participant in the Wnt signaling
pathway, influencing tumorigenesis and metastasis. However, their specific roles in the …

Myelin is essential to neuronal health and CNS function, and oligodendrocytes (OLs)
undergo a complex process of cytoskeletal remodeling to form compact myelin sheaths. We …

Abstract Dishevelled family proteins (DVL1–3), key scaffold proteins, act on canonical and
non-canonical Wnt/β-catenin signaling pathway. DVL has been implicated in various tumor …

Polo-like kinase 4 (PLK4) is the master regulator of centriole duplication in metazoan
organisms. Catalytic activity and protein turnover of PLK4 are tightly coupled in human cells …

Polo-like kinases (PLKs) belong to a five-membered family of highly conserved
serine/threonine kinases (PLK1-5) that play differentiated and essential roles as key mitotic …

Aberrated PLK4 expression has been reported in different malignancies and causes
centrosome amplification, aneuploidy, and genomic instability. However, the mechanism by …

The Wnt signaling pathways are well known for having several pivotal roles during
embryonic development. However, the same developmental signaling pathways also …