As a full-fidelity simulation of human cells, tissues, organs, and even systems at the
microscopic scale, Organ-on-a-Chip (OOC) has significant ethical advantages and …

Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in
irreversible vision loss due to the mammalian central nervous system's limited regenerative …

Retinal ganglion cells (RGCs) are the brain's gateway to the visual world. They can be
classified into different types on the basis of their electrophysiological, transcriptomic, or …

Oxytocin (OXT) neurons in paraventricular nucleus of hypothalamus (PVN) are involved in
modulating multiple functions, including social, maternal, feeding, and emotional related …

Microglia are the primary immune cells of the CNS, contributing to both inflammatory
damage and tissue repair in neurological disorder. In addition, emerging evidence …

Multi-modal single cell RNA assays capture RNA content as well as other data modalities,
such as spatial cell position or the electrophysiological properties of cells. Compared to …

The brain circuit projecting from the ventral tegmental area (VTA) to the nucleus accumbens
lateral shell (NAcLat) has a key role in methamphetamine (MA) addiction. As different …

Brain functions are fundamental for the survival of organisms, and they are supported by
neural circuits consisting of a variety of neurons. To investigate the function of neurons at the …

Neural circuits and the cells that comprise them represent the functional units of the brain.
Circuits relay and process sensory information, maintain homeostasis, drive behaviors, and …

The selective vulnerability of specific neuronal subtypes is a hallmark of neurodegenerative
diseases. In this Review, I summarize our current understanding of the brain regions and …