Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

At present, a large number of relevant studies have suggested that the changes in gut
microbiota are related to the course of nervous system diseases, and the microbiota-gut …

The immune checkpoint blockade (ICB) response in human cancers is closely linked to the
gut microbiota. Here, we report that the abundance of commensal Lactobacillus johnsonii is …

Tryptophan is catabolized by gut microorganisms resulting in a wide range of metabolites
implicated in both beneficial and adverse host effects. How gut microbial tryptophan …

Alzheimer's disease (AD) is characterized by amyloid-β accumulation in the brain and
hyperphosphorylated tau aggregation, as well as neuroinflammation. The gut–brain axis has …

Methods capable of manipulating bacterial colonization are of great significance for
modulating host-microbiota relationships. Here, we describe a strategy of in-situ chemical …

Understanding the role of the microbiome in inflammatory diseases requires the
identification of microbial effector molecules. We established an approach to link disease …

Tryptophan metabolism and gut microbiota form an integrated regulatory axis that impacts
immunity, metabolism, and cancer. This review consolidated current knowledge on the …

The epithelial tissues that line our body, such as the skin and gut, have remarkable
regenerative prowess and continually renew throughout our lifetimes. Owing to their barrier …

Background There is a growing body of evidence suggesting that disturbance of the gut-
brain axis may be one of the potential causes of major depressive disorder (MDD). However …