Important flavonoids and their role as a therapeutic agent

A Ullah, S Munir, SL Badshah, N Khan, L Ghani… - Molecules, 2020‏ - mdpi.com
Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and
leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of …

[HTML][HTML] The Characteristic of Virulence, Biofilm and Antibiotic Resistance of Klebsiella pneumoniae

G Wang, G Zhao, X Chao, L **e, H Wang - International journal of …, 2020‏ - mdpi.com
Klebsiella pneumoniae is an important gram-negative opportunistic pathogen that causes a
variety of infectious diseases, including urinary tract infections, bacteremia, pneumonia, and …

[HTML][HTML] Biological effects of quinolones: a family of broad-spectrum antimicrobial agents

AR Millanao, AY Mora, NA Villagra, SA Bucarey… - Molecules, 2021‏ - mdpi.com
Broad antibacterial spectrum, high oral bioavailability and excellent tissue penetration
combined with safety and few, yet rare, unwanted effects, have made the quinolones class of …

Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance

S Navon-Venezia, K Kondratyeva… - FEMS microbiology …, 2017‏ - academic.oup.com
Klebsiella pneumoniae is an important multidrug-resistant (MDR) pathogen affecting
humans and a major source for hospital infections associated with high morbidity and …

Delivery of antibacterial agents for wound healing applications using polysaccharide-based scaffolds

H Nosrati, M Heydari, Z Tootiaei, S Ganjbar… - Journal of Drug Delivery …, 2023‏ - Elsevier
Skin is the first line of defense against pathogenic microorganisms. Any serious damage to
this organ can lead to bacterial invasion and wound infection. Such infections can cause not …

DNA Gyrase as a Target for Quinolones

AC Spencer, SS Panda - Biomedicines, 2023‏ - mdpi.com
Bacterial DNA gyrase is a type II topoisomerase that can introduce negative supercoils to
DNA substrates and is a clinically-relevant target for the development of new antibacterials …

Recent advances in the synthetic and medicinal perspective of quinolones: A review

P Dhiman, N Arora, PV Thanikachalam, V Monga - Bioorganic Chemistry, 2019‏ - Elsevier
In the modern scenario, the quinolone scaffold has emerged as a very potent motif
considering its clinical significance. Quinolones possess wide range of pharmacological …

Recent advances in DNA gyrase-targeted antimicrobial agents

SN Dighe, TA Collet - European Journal of Medicinal Chemistry, 2020‏ - Elsevier
Antimicrobial resistance is one of the greatest challenges facing the world today. In the
United States alone, it is responsible for the death of more than 20,000 people each year …

Hydrazone comprising compounds as promising anti-infective agents: Chemistry and structure-property relationship

PC Sharma, D Sharma, A Sharma, N Saini… - Materials Today …, 2020‏ - Elsevier
Despite the adverse effects of microbial hazards on public health, major pharmaceutical
firms have left the field of anti-infective development and a dramatic reduction in the number …

Engineered Janus amphipathic polymeric fiber films with unidirectional drainage and anti-adhesion abilities to accelerate wound healing

Z Luo, L Jiang, C Xu, D Kai, X Fan, M You… - Chemical Engineering …, 2021‏ - Elsevier
Rational design of new wound dressing materials aims to accelerate wound healing.
Traditional hydrophilic wound dressings, however, tend to cause retention of wound exudate …