Spatial proteomics: a powerful discovery tool for cell biology
Protein subcellular localization is tightly controlled and intimately linked to protein function in
health and disease. Capturing the spatial proteome—that is, the localizations of proteins and …
health and disease. Capturing the spatial proteome—that is, the localizations of proteins and …
Application of machine learning in spatial proteomics
Spatial proteomics is an interdisciplinary field that investigates the localization and dynamics
of proteins, and it has gained extensive attention in recent years, especially the subcellular …
of proteins, and it has gained extensive attention in recent years, especially the subcellular …
Deep learning a boon for biophotonics?
This review covers original articles using deep learning in the biophotonic field published in
the last years. In these years deep learning, which is a subset of machine learning mostly …
the last years. In these years deep learning, which is a subset of machine learning mostly …
YeastSpotter: accurate and parameter-free web segmentation for microscopy images of yeast cells
We introduce YeastSpotter, a web application for the segmentation of yeast microscopy
images into single cells. YeastSpotter is user-friendly and generalizable, reducing the …
images into single cells. YeastSpotter is user-friendly and generalizable, reducing the …
Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast
To better understand the quantitative characteristics and structure of phenotypic diversity, we
measured over 14,000 transcript, protein, metabolite, and morphological traits in 22 …
measured over 14,000 transcript, protein, metabolite, and morphological traits in 22 …
[HTML][HTML] Harnessing sub-organelle metabolism for biosynthesis of isoprenoids in yeast
X Cao, S Yang, C Cao, YJ Zhou - Synthetic and systems biotechnology, 2020 - Elsevier
Current yeast metabolic engineering in isoprenoids production mainly focuses on rewiring of
cytosolic metabolic pathway. However, the precursors, cofactors and the enzymes are …
cytosolic metabolic pathway. However, the precursors, cofactors and the enzymes are …
CYCLoPs: a comprehensive database constructed from automated analysis of protein abundance and subcellular localization patterns in Saccharomyces cerevisiae
Abstract Changes in protein subcellular localization and abundance are central to biological
regulation in eukaryotic cells. Quantitative measures of protein dynamics in vivo are …
regulation in eukaryotic cells. Quantitative measures of protein dynamics in vivo are …
[HTML][HTML] Nuclear mRNA metabolism drives selective basket assembly on a subset of nuclear pore complexes in budding yeast
To determine which transcripts should reach the cytoplasm for translation, eukaryotic cells
have established mechanisms to regulate selective mRNA export through the nuclear pore …
have established mechanisms to regulate selective mRNA export through the nuclear pore …
YeastRGB: comparing the abundance and localization of yeast proteins across cells and libraries
B Dubreuil, E Sass, Y Nadav… - Nucleic Acids …, 2019 - academic.oup.com
The ability to measure the abundance and visualize the localization of proteins across the
yeast proteome has stimulated hypotheses on gene function and fueled discoveries. While …
yeast proteome has stimulated hypotheses on gene function and fueled discoveries. While …
Membrane-anchored ubiquitin ligase complex is required for the turnover of lysosomal membrane proteins
Cells must regulate the abundance and activity of numerous nutrient transporters in different
organelle membranes to achieve nutrient homeostasis. As the recycling center and major …
organelle membranes to achieve nutrient homeostasis. As the recycling center and major …