Focal segmental glomerulosclerosis, which is characterized by progressive glomerular
scarring, accounts for about 20% of cases of the nephrotic syndrome in children and 40% in …

The acutely injured mammalian kidney mounts a cellular and molecular response to repair
itself. However, in patchy regions such intrinsic processes are impaired and dysregulated …

The integration of single cell transcriptome and chromatin accessibility datasets enables a
deeper understanding of cell heterogeneity. We performed single nucleus ATAC (snATAC …

Renal proximal tubule epithelial cells have considerable intrinsic repair capacity following
injury. However, a fraction of injured proximal tubule cells fails to undergo normal repair and …

Gene therapy for kidney diseases has proven challenging. Adeno-associated virus (AAV) is
used as a vector for gene therapy targeting other organs, with particular success …

Whether kidney proximal tubule harbors a scattered population of epithelial stem cells is a
major unsolved question. Lineage-tracing studies, histologic characterization, and ex vivo …

Podocytes are the key target cells for injury across the spectrum of primary and secondary
proteinuric kidney disorders, which account for up to 90% of cases of kidney failure …

As an integral member of the filtration barrier in the kidney glomerulus, the podocyte is in a
unique geographical position: It is exposed to chemical signals from the urinary space …

The mammalian kidney is a vital organ with considerable cellular complexity and functional
diversity. Kidney development is notable for requiring distinct but coincident tubulogenic …

Progressive loss of podocytes is the most frequent cause accounting for end-stage renal
failure. Podocytes are complex, terminally differentiated cells incapable of replicating. Thus …