Understanding the molecular mechanisms underlying synergistic, potentiative and
antagonistic effects of drug combinations could facilitate the discovery of novel efficacious …

This review examined a collection of studies regarding the molecular properties of some
polyene antibiotic molecules as well as their properties in solution and in particular …

We report on the modification of membranes by incorporation of phenylenevinylene
oligoelectrolytes with the goal of tailoring their optical and electronic properties and their …

Polyene antifungal amphotericin B (AmB) has been used for over 60 years, and remains a
valuable clinical treatment for systemic mycoses, due to its broad antifungal activity and low …

Fungal infection poses a major global threat to public health because of its wide prevalence,
severe mortality rate, challenges involved in diagnosis and treatment, and the emergence of …

Cutaneous leishmaniasis is the most common form of leishmaniasis and the available
chemotherapy causes serious side effects, justifying the search for new therapies. This study …

A anfotericina B, fármaco descoberto em 1953, ainda permanece como substância
fungicida de escolha no tratamento da maioria das micoses sistêmicas que acometem …

Amphotericin B (AMB) is an effective antifungal agent. However, its therapeutic use is
hampered by its toxicity, mainly due to channel formation across kidney cell membranes and …

Topical application of antifungals does not have predictable or well-controlled release
characteristics and requires reapplication to achieve therapeutic local concentration in a …

The growth of antibiotic resistance to antifungal drugs contributes to the search for new ways
to enhance their effectiveness and reduce toxicity. The undeniable advantage of polyene …