While a high rate of cell loss is tolerated and even required to model the develo** nervous
system, an increased rate of cell death in the adult nervous system underlies …

The object of this review is to assemble much of the literature concerning Purkinje cell death
in cerebellar pathology and to relate this to what is now known about the complex …

A rapid and simple procedure is presented to obtain nearly pure populations of human
neuron‐like cells from the SH‐SY5Y neuroblastoma cell line. Sequential exposure of SH …

Background Chemotherapy in cancer patients can be associated with serious short-and
long-term adverse neurological effects, such as leukoencephalopathy and cognitive …

Apoptosis is one of the two forms of cell death and occurs under a variety of physiological
and pathological conditions. Cells undergoing apoptotic cell death reveal a characteristic …

Camptothecin is an S-phase-specific anticancer agent that inhibits the activity of the enzyme
DNA topoisomerase-I (topo-I). Irreversible DNA double-strand breaks are produced during …

Activation of caspase-3 requires proteolytic processing of the inactive zymogen into p18 and
p12 subunits. We generated a rabbit polyclonal antiserum, CM1, which recognizes the p18 …

The antimitotic nucleoside cytosine arabinoside (araC) causes apoptosis in postmitotic
neurons for which two mechanisms have been suggested:(1) araC directly inhibits a trophic …

Perineuronal nets (PNNs) are lattice-like substructures of the neural extracellular matrix that
enwrap particular populations of neurons throughout the central nervous system. Previous …

This is the report of the first workshop on Incorporating In Vitro Alternative Methods for
Developmental Neurotoxicity (DNT) Testing into International Hazard and Risk Assessment …