Lyme disease (also known as Lyme borreliosis) is the most common vector-borne disease in
the United States with an estimated 476,000 cases per year. While historically, the long-term …

As long-term pool feeders, ticks have developed myriad strategies to remain discreetly but
solidly attached to their hosts for the duration of their blood meal. The critical biological …

Ticks transmit the most diverse array of infectious agents of any arthropod vector. Both ticks
and the microbes they transmit are recognized as significant threats to human and veterinary …

Ticks secrete various anti-coagulatory, anti-vasoconstrictory, anti-inflammatory, and anti-
platelet aggregation factors in their saliva at the bite site during feeding to evade host …

Ticks can transmit a variety of human pathogens, including intracellular and extracellular
bacteria, viruses, and protozoan parasites. Historically, their saliva has been of immense …

In Lyme borreliosis, the skin constitutes a major interface for the host, the bacteria and the
tick. Skin immunity is provided by specialized immune cells but also by the resident cells: the …

Significant new insights are being made into tick modulation of host immune defenses and
the implications of those host defense changes on tick-borne pathogen transmission and …

The skin plays a key role in vector-borne diseases because it is the site where the arthropod
coinoculates pathogens and its saliva. Lyme borreliosis, particularly well investigated in this …

Little is known about the immunomodulation by tick saliva during a natural tick bite in human
skin, the site of the tick‐host interaction. We examined the expression of chemokines …

Background Ticks are major vectors of diseases affecting humans such as Lyme disease or
domestic animals such as anaplasmosis. Cross-alteration of the vertebrate host skin …