Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases
G Wigerblad, MJ Kaplan - Nature Reviews Immunology, 2023 - nature.com
Systemic autoimmune diseases are characterized by the failure of the immune system to
differentiate self from non-self. These conditions are associated with significant morbidity …
differentiate self from non-self. These conditions are associated with significant morbidity …
Systemic lupus erythematosus pathogenesis: interferon and beyond
Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …
Single-cell RNA-seq reveals cell type–specific molecular and genetic associations to lupus
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. Knowledge
of circulating immune cell types and states associated with SLE remains incomplete. We …
of circulating immune cell types and states associated with SLE remains incomplete. We …
Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a life-threatening autoimmune disease characterized
by adaptive immune system activation, formation of double-stranded DNA autoantibodies …
by adaptive immune system activation, formation of double-stranded DNA autoantibodies …
B cell depletion therapies in autoimmune disease: advances and mechanistic insights
DSW Lee, OL Rojas, JL Gommerman - Nature reviews Drug discovery, 2021 - nature.com
In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …
active participants in autoimmune aetiology. This has been fuelled in part by the clinical …
Lupus nephritis
Lupus nephritis (LN) is a form of glomerulonephritis that constitutes one of the most severe
organ manifestations of the autoimmune disease systemic lupus erythematosus (SLE). Most …
organ manifestations of the autoimmune disease systemic lupus erythematosus (SLE). Most …
Pathogenesis of systemic lupus erythematosus: risks, mechanisms and therapeutic targets
MK Crow - Annals of the rheumatic diseases, 2023 - ard.bmj.com
Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …
Autoimmunity and organ damage in systemic lupus erythematosus
GC Tsokos - Nature immunology, 2020 - nature.com
Impressive progress has been made over the last several years toward understanding how
almost every aspect of the immune system contributes to the expression of systemic …
almost every aspect of the immune system contributes to the expression of systemic …
Map** systemic lupus erythematosus heterogeneity at the single-cell level
Patients with systemic lupus erythematosus (SLE) display a complex blood transcriptome
whose cellular origin is poorly resolved. Using single-cell RNA sequencing, we profiled …
whose cellular origin is poorly resolved. Using single-cell RNA sequencing, we profiled …
[HTML][HTML] Trial of anifrolumab in active systemic lupus erythematosus
Background Anifrolumab, a human monoclonal antibody to type I interferon receptor subunit
1 investigated for the treatment of systemic lupus erythematosus (SLE), did not have a …
1 investigated for the treatment of systemic lupus erythematosus (SLE), did not have a …