Both aging and cancer are characterized by a series of partially overlap**" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …

Metabolic reprogramming in cancer is not only a biological hallmark but also reveals
treatment vulnerabilities. Numerous metabolic molecules have shown promise as treatment …

Metastasis is the major cause of cancer deaths, and cancer cells evolve to adapt to various
tumor microenvironments, which hinders the treatment of tumor metastasis. Platelets play …

Protein lysine crotonylation has been recently identified as a vital posttranslational
modification in cellular processes, particularly through the modification of histones. We show …

Alkaliptosis, a type of regulated cell death driven by intracellular alkalization, was first
described in pancreatic ductal adenocarcinoma (PDAC) cells after treatment with the opioid …

Increasing evidence implicates the critical roles of various epitranscriptomic RNA
modifications in different biological processes. Methyltransferase METTL8 installs 3 …

Advanced prostate cancers are treated with therapies targeting the androgen receptor (AR)
signaling pathway. While many tumors initially respond to AR inhibition, nearly all develop …

Endometrial cancer (EC) is the most prevalent gynecological malignancy, with a higher risk
in obese woman, indicating the possibility of gut microbiota involvement in EC progression …

In castration-resistant prostate cancer (CRPC), clinical response to androgen receptor (AR)
antagonists is limited mainly due to AR-variants expression and restored AR signaling. The …

Metabolic dysregulations have emerged as a major mediator of cardiovascular disorders
and fibrotic diseases. Metabolic reprogramming contributes a lot to cardiac fibroblast …