Recent advance in the development of novel, selective and potent FGFR inhibitors

FT Liu, NG Li, YM Zhang, WC **e, SP Yang, T Lu… - European journal of …, 2020 - Elsevier
Mutation or abnormal expression of protein tyrosine kinases (PTKs) is one of the main
causes of cancer. Fibroblast growth factor receptors (FGFRs) are a subfamily of tyrosine …

Design, synthesis and antitumor activity of novel pyrazolo [3, 4-d] pyrimidine derivatives as EGFR-TK inhibitors

MA Abdelgawad, RB Bakr, OA Alkhoja… - Bioorganic chemistry, 2016 - Elsevier
Abstract A novel series of 2-(3, 6-dimethyl-1-phenyl-1H-pyrazolo [3, 4-d] pyrimidin-4-yloxy)-
N-(4-substitutedbenzylidene) acetohydrazide (12a–g) was prepared and their structures …

Synthesis, characterization, linear and NLO properties of novel N-(2, 4-dinitrobenzylidene)-3-chlorobenzenamine schiff base: combined experimental and DFT …

A Benmohammed, D Hadji, A Guendouzi… - Journal of Electronic …, 2021 - Springer
This study entails two parts: The first reports on the synthesis of a novel N-(2, 4-
dinitrobenzylidene)-3-chlorobenzenamine Schiff base and its analysis by ultraviolet–visible …

[HTML][HTML] An Insight into Rational Drug Design: The Development of In-House Azole Compounds with Antimicrobial Activity

D Ungureanu, O Oniga, C Moldovan, I Ionuț, G Marc… - Antibiotics, 2024 - mdpi.com
Antimicrobial resistance poses a major threat to global health as the number of efficient
antimicrobials decreases and the number of resistant pathogens rises. Our research group …

The molecular structure, spectroscopic features and electronic properties of tioxolone under the external electric field

Y Tao, Q Wang, K Sun, Q Zhang, W Liu, J Du… - Spectrochimica Acta Part …, 2020 - Elsevier
It is very helpful to understand the properties of molecules by studying a series of physical
and chemical changes in molecules under an external electric field (EEF). Tioxolone is an …

[HTML][HTML] Novel Aminopyrimidine-2, 4-diones, 2-Thiopyrimidine-4-ones, and 6-Arylpteridines as Dual-Target Inhibitors of BRD4/PLK1: Design, Synthesis, Cytotoxicity …

S El-Kalyoubi, SA El-Sebaey, SM Elfeky… - Pharmaceuticals, 2023 - mdpi.com
Structural-based drug design and solvent-free synthesis were combined to obtain three
novel series of 5-arylethylidene-aminopyrimidine-2, 4-diones (4, 5a–c, 6a, b), 5 …

Synthesis and characterization of fluorenone derivatives with electrical properties explored using density functional theory (DFT)

MU Farooq, M Muneer, A Shahid, MA Rehman… - Scientific Reports, 2024 - nature.com
This study provides thorough computational and experimental assessments of four types of
novel synthesized thiosemicarbazones. The compounds were effectively synthesized using …

New Thiazolyl-triazole Schiff Bases: Synthesis and Evaluation of the Anti-Candida Potential

A Stana, A Enache, DC Vodnar, C Nastasă, D Benedec… - Molecules, 2016 - mdpi.com
In the context of the dangerous phenomenon of fungal resistance to the available therapies,
we present here the chemical synthesis of a new series of thiazolyl-triazole Schiff bases B1 …

[HTML][HTML] The Advantage of Automatic Peer-Reviewing of 13C-NMR Reference Data Using the CSEARCH-Protocol

W Robien - Molecules, 2021 - mdpi.com
A systematic investigation of the experimental 13C-NMR spectra published in Molecules
during the period of 1996 to 2015 with respect to their quality using CSEARCH-technology is …

Enhanced tumor delivery and antitumor response of doxorubicin-loaded albumin nanoparticles formulated based on a Schiff base

F Li, C Zheng, J **n, F Chen, H Ling, L Sun… - International journal …, 2016 - Taylor & Francis
A novel method was developed here to prepare albumin-based nanoparticles (NPs) for
improving the therapeutic and safety profiles of chemotherapeutic agents. This approach …