Hybrid modeling in bioprocess dynamics: Structural variabilities, implementation strategies, and practical challenges
B Mahanty - Biotechnology and Bioengineering, 2023 - Wiley Online Library
Hybrid modeling, with an appropriate blend of the mechanistic and data‐driven framework,
is increasingly being adopted in bioprocess modeling, model‐based experimental design …
is increasingly being adopted in bioprocess modeling, model‐based experimental design …
Scientific novelty beyond the experiment
Practical experiments drive important scientific discoveries in biology, but theory‐based
research studies also contribute novel—sometimes paradigm‐changing—findings. Here, we …
research studies also contribute novel—sometimes paradigm‐changing—findings. Here, we …
[HTML][HTML] Artificial intelligence and bioinformatics: a journey from traditional techniques to smart approaches
H Jamialahmadi, G Khalili-Tanha… - … from Bed to Bench, 2024 - pmc.ncbi.nlm.nih.gov
The incorporation of AI models into bioinformatics has brought about a revolutionary era in
the analysis and interpretation of biological data. This mini-review offers a succinct overview …
the analysis and interpretation of biological data. This mini-review offers a succinct overview …
Design patterns for the construction of computational biological models
Computational biological models have proven to be an invaluable tool for understanding
and predicting the behaviour of many biological systems. While it may not be too …
and predicting the behaviour of many biological systems. While it may not be too …
Addressing data uncertainty of Caulobacter crescentus cell cycles using hybrid Petri nets with fuzzy kinetics
Studying and analysing the various phases and key proteins of cell cycles is essential for the
understanding of cell development and differentiation. To this end, mechanistic models play …
understanding of cell development and differentiation. To this end, mechanistic models play …
Splittable systems in biomedical applications
Splittable systems have emerged as a powerful approach for the precise spatiotemporal
control of biological processes. This concept relies on splitting a functional molecule into …
control of biological processes. This concept relies on splitting a functional molecule into …
A workflow for the hybrid modelling and simulation of multi-timescale biological systems
With the steady advance of in-silico biological experimentation, model construction and
simulation becomes a ubiquitous tool to understand and predict the behaviour of many …
simulation becomes a ubiquitous tool to understand and predict the behaviour of many …
Bridging systems biology and tissue engineering: Unleashing the full potential of complex 3D in vitro tissue models of disease
Rapid advances in tissue engineering have resulted in more complex and physiologically
relevant 3D in vitro tissue models with applications in fundamental biology and therapeutic …
relevant 3D in vitro tissue models with applications in fundamental biology and therapeutic …
Targeted quantification of protein phosphorylation and its contributions towards mathematical modeling of signaling pathways
Post-translational modifications (PTMs) are key regulatory mechanisms that can control
protein function. Of these, phosphorylation is the most common and widely studied. Because …
protein function. Of these, phosphorylation is the most common and widely studied. Because …
Arduino Soft Sensor for Monitoring Schizochytrium sp. Fermentation, a Proof of Concept for the Industrial Application of Genome-Scale Metabolic Models in the …
C Alarcon, C Shene - Processes, 2022 - mdpi.com
Schizochytrium sp. is a microorganism cultured for producing docosahexaenoic acid (DHA).
Genome-scale metabolic modeling (GEM) is a promising technique for describing gen …
Genome-scale metabolic modeling (GEM) is a promising technique for describing gen …