Congenital heart disease (CHD) is the most common birth defect worldwide and the number
one killer of live-born infants in the United States. Heart development occurs early in …

Progression of cells through distinct phases of the cell cycle, and transition into out-of-
cycling states, such as terminal differentiation and senescence, is accompanied by specific …

SETD1A, a lysine-methyltransferase, is a key schizophrenia susceptibility gene. Mice
carrying a heterozygous loss-of-function mutation of the orthologous gene exhibit alterations …

Background: Correct gene expression programming of the cardiomyocyte underlies the
normal functioning of the heart. Alterations to this can lead to the loss of cardiac …

Identification of structurally novel inhibitors of lysine methyltransferase G9a has been a
subject of intense research in cancer epigenetics. Starting with the high-throughput …

The discovery and development of structurally distinct lysine methyltransferase G9a
inhibitors have been the subject of intense research in epigenetics. Structure-based …

The systematic mutation of histone 3 (H3) genes in model organisms has proven to be a
valuable tool to distinguish the functional role of histone residues. No system exists in …

Histone methylation, a crucial aspect of epigenetics, intricately involves specialized
enzymes such as G9a, a histone methyltransferase (HMT) catalyzing the methylation of …

RING1 and YY1 binding protein (RYBP) is primarily known to function as a repressor being
a core component of the non-canonical polycomb repressive complexes 1 (ncPRC1s) …

The process by which fibroblasts are directly reprogrammed into cardiomyocytes involves
two stages; initiation and maturation. Initiation represents the initial expression of factors that …