Updated review of advances in microRNAs and complex diseases: taxonomy, trends and challenges of computational models

L Huang, L Zhang, X Chen - Briefings in bioinformatics, 2022 - academic.oup.com
Since the problem proposed in late 2000s, microRNA–disease association (MDA)
predictions have been implemented based on the data fusion paradigm. Integrating diverse …

Updated review of advances in microRNAs and complex diseases: towards systematic evaluation of computational models

L Huang, L Zhang, X Chen - Briefings in bioinformatics, 2022 - academic.oup.com
Currently, there exist no generally accepted strategies of evaluating computational models
for microRNA-disease associations (MDAs). Though K-fold cross validations and case …

HINGRL: predicting drug–disease associations with graph representation learning on heterogeneous information networks

BW Zhao, L Hu, ZH You, L Wang… - Briefings in …, 2022 - academic.oup.com
Identifying new indications for drugs plays an essential role at many phases of drug
research and development. Computational methods are regarded as an effective way to …

Updated review of advances in microRNAs and complex diseases: experimental results, databases, webservers and data fusion

L Huang, L Zhang, X Chen - Briefings in bioinformatics, 2022 - academic.oup.com
MicroRNAs (miRNAs) are gene regulators involved in the pathogenesis of complex
diseases such as cancers, and thus serve as potential diagnostic markers and therapeutic …

Predicting miRNA–disease associations via learning multimodal networks and fusing mixed neighborhood information

Z Lou, Z Cheng, H Li, Z Teng, Y Liu… - Briefings in …, 2022 - academic.oup.com
Motivation In recent years, a large number of biological experiments have strongly shown
that miRNAs play an important role in understanding disease pathogenesis. The discovery …

Predicting miRNA-disease associations via node-level attention graph auto-encoder

H Zhang, J Fang, Y Sun, G **e, Z Lin… - IEEE/ACM Transactions …, 2022 - ieeexplore.ieee.org
Previous studies have confirmed microRNA (miRNA), small single-stranded non-coding
RNA, participates in various biological processes and plays vital roles in many complex …

Predicting miRNA-disease association via graph attention learning and multiplex adaptive modality fusion

Z **, M Wang, C Tang, X Zheng, W Zhang… - Computers in Biology …, 2024 - Elsevier
Abstract miRNAs are a class of small non-coding RNA molecules that play important roles in
gene regulation. They are crucial for maintaining normal cellular functions, and …

Mgcnss: mirna–disease association prediction with multi-layer graph convolution and distance-based negative sample selection strategy

Z Tian, C Han, L Xu, Z Teng… - Briefings in …, 2024 - academic.oup.com
Identifying disease-associated microRNAs (miRNAs) could help understand the deep
mechanism of diseases, which promotes the development of new medicine. Recently …

IP-GCN: A deep learning model for prediction of insulin using graph convolutional network for diabetes drug design

F Ali, M Khalid, A Almuhaimeed, A Masmoudi… - Journal of …, 2024 - Elsevier
Insulin is a kind of protein that regulates the blood sugar levels is significant to prevent
complications associated with diabetes, such as cancer, neurodegenerative disorders …

Explainable and programmable hypergraph convolutional network for imaging genetics data fusion

X Bi, S Luo, S Jiang, Y Wang, Z **ng, L Xu - Information Fusion, 2023 - Elsevier
Integrating multi-view information to gain a new understanding of complex disease like
Alzheimer's disease (AD) has great clinical value. Hypergraphs have unique advantages in …