A guide to plasma membrane solute carrier proteins
This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily
of transporter proteins and their roles in human cells. The SLC superfamily currently …
of transporter proteins and their roles in human cells. The SLC superfamily currently …
[HTML][HTML] The mechanisms of pharmacokinetic food-drug interactions–A perspective from the UNGAP group
The simultaneous intake of food and drugs can have a strong impact on drug release,
absorption, distribution, metabolism and/or elimination and consequently, on the efficacy …
absorption, distribution, metabolism and/or elimination and consequently, on the efficacy …
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
Transporters and drug-drug interactions: important determinants of drug disposition and effects
Uptake and efflux transporters determine plasma and tissue concentrations of a broad
variety of drugs. They are localized in organs such as small intestine, liver, and kidney …
variety of drugs. They are localized in organs such as small intestine, liver, and kidney …
OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies
M Roth, A Obaidat, B Hagenbuch - British journal of …, 2012 - Wiley Online Library
The human organic anion and cation transporters are classified within two SLC
superfamilies. Superfamily SLCO (formerly SLC21A) consists of organic anion transporting …
superfamilies. Superfamily SLCO (formerly SLC21A) consists of organic anion transporting …
Impact of OATP transporters on pharmacokinetics
A Kalliokoski, M Niemi - British journal of pharmacology, 2009 - Wiley Online Library
Membrane transporters are now recognized as important determinants of the
transmembrane passage of drugs. Organic anion transporting polypeptides (OATP) form a …
transmembrane passage of drugs. Organic anion transporting polypeptides (OATP) form a …
Fingerprinting food: current technologies for the detection of food adulteration and contamination
Major food adulteration and contamination events seem to occur with some regularity, such
as the widely publicised adulteration of milk products with melamine and the recent …
as the widely publicised adulteration of milk products with melamine and the recent …
Coexistence of passive and carrier-mediated processes in drug transport
The permeability of biological membranes is one of the most important determinants of the
pharmacokinetic processes of a drug. Although it is often accepted that many drug …
pharmacokinetic processes of a drug. Although it is often accepted that many drug …
Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake
M Niemi, MK Pasanen, PJ Neuvonen, M Koulu - Pharmacological reviews, 2011 - Elsevier
The importance of membrane transporters for drug pharmacokinetics has been increasingly
recognized during the last decade. Organic anion transporting polypeptide 1B1 (OATP1B1) …
recognized during the last decade. Organic anion transporting polypeptide 1B1 (OATP1B1) …
Bile acid transporters
PA Dawson, T Lan, A Rao - Journal of lipid research, 2009 - ASBMB
In liver and intestine, transporters play a critical role in maintaining the enterohepatic
circulation and bile acid homeostasis. Over the past two decades, there has been significant …
circulation and bile acid homeostasis. Over the past two decades, there has been significant …