Utility of B-factors in protein science: interpreting rigidity, flexibility, and internal motion and engineering thermostability
Z Sun, Q Liu, G Qu, Y Feng, MT Reetz - Chemical reviews, 2019 - ACS Publications
The term B-factor, sometimes called the Debye–Waller factor, temperature factor, or atomic
displacement parameter, is used in protein crystallography to describe the attenuation of X …
displacement parameter, is used in protein crystallography to describe the attenuation of X …
Evolutionary pathways and trajectories in antibiotic resistance
Evolution is the hallmark of life. Descriptions of the evolution of microorganisms have
provided a wealth of information, but knowledge regarding “what happened” has precluded …
provided a wealth of information, but knowledge regarding “what happened” has precluded …
The surprising creativity of digital evolution: A collection of anecdotes from the evolutionary computation and artificial life research communities
Evolution provides a creative fount of complex and subtle adaptations that often surprise the
scientists who discover them. However, the creativity of evolution is not limited to the natural …
scientists who discover them. However, the creativity of evolution is not limited to the natural …
Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation
Organisms are constantly exposed to a wide range of environmental changes, including
both short-term changes during their lifetime and longer-term changes across generations …
both short-term changes during their lifetime and longer-term changes across generations …
The problem of fragmentation and the need for integrative solutions
KC Stange - The Annals of Family Medicine, 2009 - Annals Family Med
EDITORIALS to breathtaking advances from isolating, partitioning, and manipulating the
components of physical, biological, and human systems. More recently, new insights in …
components of physical, biological, and human systems. More recently, new insights in …
Do we need an extended evolutionary synthesis?
M Pigliucci - Evolution, 2007 - academic.oup.com
Abstract The Modern Synthesis (MS) is the current paradigm in evolutionary biology. It was
actually built by expanding on the conceptual foundations laid out by its predecessors …
actually built by expanding on the conceptual foundations laid out by its predecessors …
Plasmids foster diversification and adaptation of bacterial populations in soil
H Heuer, K Smalla - FEMS microbiology reviews, 2012 - academic.oup.com
It is increasingly being recognized that the transfer of conjugative plasmids across species
boundaries plays a vital role in the adaptability of bacterial populations in soil. There are …
boundaries plays a vital role in the adaptability of bacterial populations in soil. There are …
Life is physics: evolution as a collective phenomenon far from equilibrium
N Goldenfeld, C Woese - Annu. Rev. Condens. Matter Phys., 2011 - annualreviews.org
Evolution is the fundamental physical process that gives rise to biological phenomena. Yet it
is widely treated as a subset of population genetics, and thus its scope is artificially limited …
is widely treated as a subset of population genetics, and thus its scope is artificially limited …
Mutational robustness can facilitate adaptation
Robustness seems to be the opposite of evolvability. If phenotypes are robust against
mutation, we might expect that a population will have difficulty adapting to an environmental …
mutation, we might expect that a population will have difficulty adapting to an environmental …
Quantitative analyses of empirical fitness landscapes
The concept of a fitness landscape is a powerful metaphor that offers insight into various
aspects of evolutionary processes and guidance for the study of evolution. Until recently …
aspects of evolutionary processes and guidance for the study of evolution. Until recently …