Complement Inhibitors for Advanced Dry Age-Related Macular Degeneration (Geographic Atrophy): Some Light at the End of the Tunnel?
M Cruz-Pimentel, L Wu - Journal of Clinical Medicine, 2023 - mdpi.com
Geographic atrophy (GA) affects around 5 million individuals worldwide. Genome-wide,
histopathologic, in vitro and animal studies have implicated the activation of the complement …
histopathologic, in vitro and animal studies have implicated the activation of the complement …
AI in the clinical management of GA: a novel therapeutic universe requires novel tools
GS Reiter, J Mai, S Riedl, K Birner, S Frank… - Progress in Retinal and …, 2024 - Elsevier
Regulatory approval of the first two therapeutic substances for the management of
geographic atrophy (GA) secondary to age-related macular degeneration (AMD) is a major …
geographic atrophy (GA) secondary to age-related macular degeneration (AMD) is a major …
[HTML][HTML] Predicting topographic disease progression and treatment response of pegcetacoplan in geographic atrophy quantified by deep learning
Purpose To identify disease activity and effects of intravitreal pegcetacoplan treatment on
the topographic progression of geographic atrophy (GA) secondary to age-related macular …
the topographic progression of geographic atrophy (GA) secondary to age-related macular …
[HTML][HTML] Disease activity and therapeutic response to pegcetacoplan for geographic atrophy identified by deep learning-based analysis of OCT
Purpose To quantify morphological changes of the photoreceptors (PRs) and retinal pigment
epithelium (RPE) layers under pegcetacoplan therapy in geographic atrophy (GA) using …
epithelium (RPE) layers under pegcetacoplan therapy in geographic atrophy (GA) using …
The effect of complement C3 or C5 inhibition on geographic atrophy secondary to age-related macular degeneration: A living systematic review and meta-analysis
With the introduction of therapies to treat geographic atrophy (GA), GA management in
clinical practice is now possible. A living systematic review can provide access to timely and …
clinical practice is now possible. A living systematic review can provide access to timely and …
Clinical validation for automated geographic atrophy monitoring on OCT under complement inhibitory treatment
Geographic atrophy (GA) represents a late stage of age-related macular degeneration,
which leads to irreversible vision loss. With the first successful therapeutic approach, namely …
which leads to irreversible vision loss. With the first successful therapeutic approach, namely …
Deep-learning-based automated measurement of outer retinal layer thickness for use in the assessment of age-related macular degeneration, applicable to both …
Effective biomarkers are required for assessing the progression of age-related macular
degeneration (AMD), a prevalent and progressive eye disease. This paper presents a deep …
degeneration (AMD), a prevalent and progressive eye disease. This paper presents a deep …
Unleashing the power of optical attenuation coefficients to facilitate segmentation strategies in OCT imaging of age-related macular degeneration: perspective
The use of optical attenuation coefficients (OAC) in optical coherence tomography (OCT)
imaging of the retina has improved the segmentation of anatomic layers compared with …
imaging of the retina has improved the segmentation of anatomic layers compared with …
Association of complement C3 inhibitor pegcetacoplan with reduced photoreceptor degeneration beyond areas of geographic atrophy
M Pfau, S Schmitz-Valckenberg, R Ribeiro, R Safaei… - Scientific Reports, 2022 - nature.com
Preservation of photoreceptors beyond areas of retinal pigment epithelium atrophy is a
critical treatment goal in eyes with geographic atrophy (GA) to prevent vision loss. Thus, we …
critical treatment goal in eyes with geographic atrophy (GA) to prevent vision loss. Thus, we …
[HTML][HTML] Vision loss reduction with avacincaptad pegol for geographic atrophy: a 12-month post hoc analysis of the GATHER1 and GATHER2 trials
Purpose To evaluate the impact of reduction in geographic atrophy (GA) lesion growth on
visual acuity in the GATHER trials using categorical outcome measures. Design …
visual acuity in the GATHER trials using categorical outcome measures. Design …