Functional specificity in biomolecular condensates revealed by genetic complementation
Biomolecular condensates are thought to create subcellular microenvironments that
regulate specific biochemical activities. Extensive in vitro work has helped link condensate …
regulate specific biochemical activities. Extensive in vitro work has helped link condensate …
[HTML][HTML] Amyotrophic Lateral Sclerosis: Insights and New Prospects in Disease Pathophysiology, Biomarkers and Therapies
Amyotrophic Lateral Sclerosis (ALS) is a severe neurodegenerative disorder marked by the
gradual loss of motor neurons, leading to significant disability and eventual death. Despite …
gradual loss of motor neurons, leading to significant disability and eventual death. Despite …
Friend or foe: The role of stress granule in neurodegenerative disease
Q Cui, Z Liu, G Bai - Neuron, 2024 - cell.com
Stress granules (SGs) are dynamic membraneless organelles that form in response to
cellular stress. SGs are predominantly composed of RNA and RNA-binding proteins that …
cellular stress. SGs are predominantly composed of RNA and RNA-binding proteins that …
Comparative evaluation of cell-based assay technologies for scoring drug-induced condensation of SARS-CoV-2 nucleocapsid protein
Protein-nucleic acid phase separation has been implicated in many diseases such as viral
infections, neurodegeneration, and cancer. There is great interest in identifying condensate …
infections, neurodegeneration, and cancer. There is great interest in identifying condensate …