Most vertebrate olfactory receptor neurons share a common G-protein–coupled pathway for
transducing the binding of odorant into depolarization. The depolarization involves 2 …

The olfactory system gives us an awareness of our immediate environment by allowing us to
detect airborne stimuli. The components necessary for detection of these odorants are …

Defects in cilia are associated with several human disorders, including Kartagener
syndrome, polycystic kidney disease,, nephronophthisis and hydrocephalus. We proposed …

Touch and mechanical pain are first detected at our largest sensory surface, the skin. The
cell bodies of sensory neurons that detect such stimuli are located in the dorsal root ganglia …

Odorants activate sensory transduction in olfactory receptor neurons (ORNs) via a cAMP-
signaling cascade, which results in the opening of nonselective, cyclic nucleotide–gated …

Bardet–Biedl syndrome (BBS) is a pleiotropic, heterogeneous human disease whose
etiology lies primarily in dysfunctional basal bodies and/or cilia. Both BBS patients and …

Olfactory sensory neurons expose to the inhaled air chemosensory cilia which bind odorants
and operate as transduction organelles. Odorant receptors in the ciliary membrane activate …

The ability of animals to sense and differentiate among thousands of odorants relies on a
large set of olfactory receptors (OR) and a multitude of accessory proteins within the …

Abstract Purpose: Stomatin-like protein 2 (SLP-2) is a novel and unusual stomatin
homologue of unknown functions. It has been implicated in interaction with erythrocyte …

An organism's awareness of its surroundings is dependent on sensory function. As antennas
to our external environment, cilia are involved in fundamental biological processes such as …