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[HTML][HTML] Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)
Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of disease phenotypes
which start with simple steatosis and lipid accumulation in the hepatocytes-a typical …
which start with simple steatosis and lipid accumulation in the hepatocytes-a typical …
Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …
Gut microbiota in overweight and obesity: crosstalk with adipose tissue
Overweight and obesity are characterized by excessive fat mass accumulation produced
when energy intake exceeds energy expenditure. One plausible way to control energy …
when energy intake exceeds energy expenditure. One plausible way to control energy …
PPARs as metabolic regulators in the liver: lessons from liver-specific PPAR-null mice
Peroxisome proliferator-activated receptor (PPAR) α, β/δ, and γ modulate lipid homeostasis.
PPARα regulates lipid metabolism in the liver, the organ that largely controls whole-body …
PPARα regulates lipid metabolism in the liver, the organ that largely controls whole-body …
CPT1A-mediated fat oxidation, mechanisms, and therapeutic potential
Energy homeostasis during fasting or prolonged exercise depends on mitochondrial fatty
acid oxidation (FAO). This pathway is crucial in many tissues with high energy demand and …
acid oxidation (FAO). This pathway is crucial in many tissues with high energy demand and …
[HTML][HTML] Mechanisms of insulin action and insulin resistance
The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …
research into insulin action and resistance has issued. In the intervening century, some …
A 5: 2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1
The role and molecular mechanisms of intermittent fasting (IF) in non-alcoholic
steatohepatitis (NASH) and its transition to hepatocellular carcinoma (HCC) are unknown …
steatohepatitis (NASH) and its transition to hepatocellular carcinoma (HCC) are unknown …
Molecular Actions of PPARα in Lipid Metabolism and Inflammation
Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …
Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors
The increasing epidemic of obesity worldwide is linked to serious health effects, including
increased prevalence of type 2 diabetes mellitus, cardiovascular disease and nonalcoholic …
increased prevalence of type 2 diabetes mellitus, cardiovascular disease and nonalcoholic …
[HTML][HTML] Fatty acid synthase: an emerging target in cancer
In recent years, lipid metabolism has garnered significant attention as it provides the
necessary building blocks required to sustain tumor growth and serves as an alternative fuel …
necessary building blocks required to sustain tumor growth and serves as an alternative fuel …