The nucleosomal subunit organization of chromatin provides a multitude of functions.
Nucleosomes elicit an initial∼ 7-fold linear compaction of genomic DNA. They provide a …

Histone posttranslational modifications are key components of diverse processes that
modulate chromatin structure. These marks function as signals during various chromatin …

Histone proteins and the nucleosomes they form with DNA are the fundamental building
blocks of eukaryotic chromatin. A diverse array of post-translational modifications that often …

We have generated and characterized a novel site-specific antibody highly specific for the
phosphorylated form of the amino-terminus of histone H3 (Ser10). In this study, we used this …

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …

We report here purification and characterization of chro-mosome condensation protein
complexes (termed condensins) containing XCAP-C and XCAP-E, two Xenopus members of …

Phosphorylation of histone H3 at serine 10 occurs during mitosis in diverse eukaryotes and
correlates closely with mitotic and meiotic chromosome condensation. To better understand …

Despite a great deal of attention over many years, the structural and functional roles of the
linker histone H1 remain enigmatic. The earlier concepts of H1 as a general transcriptional …

The general inhibition in transcriptional activity during mitosis abolishes the stress-inducible
expression of the human hsp70 gene. Among the four transcription factors that bind to the …

Abstract CATECHOL O-methyltransferase (COMT, EC 2.1. 1.6) is important in the central
nervous system because it metabolizes catecholamine neurotransmitters such as dopamine …