The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …

BACKGROUND In adult mammalian organisms, multiple tissues—including the skin, blood,
stomach, and intestines—are entrapped in a state of permanent regeneration; older cells are …

Symbionts play an indispensable role in gut homeostasis, but underlying mechanisms
remain elusive. To clarify the role of lactic-acid-producing bacteria (LAB) on intestinal stem …

Prostate cancer is initially responsive to androgen deprivation, but the effectiveness of
androgen receptor (AR) inhibitors in recurrent disease is variable. Biopsy of bone …

Colorectal cancer (CRC) is one of the most common malignant tumor types occurring in the
digestive system. The incidence of CRC has exhibits yearly increases and the mortality rate …

Enhanced sensitivity to Wnts is an emerging hallmark of a subset of cancers, defined in part
by mutations regulating the abundance of their receptors. Whether these mutations identify a …

Several signaling pathways have been identified as important for developmental processes.
One of such important cascades is the Wnt/β‐catenin signaling pathway, which can regulate …

WNT/β-catenin signalling is crucial for intestinal homoeostasis. The intestinal epithelium and
stroma are the major source of WNT ligands but their origin and role in intestinal stem cell …

Wnt/β-catenin signaling supports intestinal homeostasis by regulating proliferation in the
crypt. Multiple Wnts are expressed in Paneth cells as well as other intestinal epithelial and …

Porcupine (PORCN) is a membrane bound O-acyltransferase that is required for Wnt
palmitoylation, secretion, and biologic activity. All evaluable human Wnts require PORCN for …