Planarians are members of the Platyhelminthes (flatworms). These animals have evolved a
remarkable stem cell system. A single pluripotent adult stem cell type (“neoblast”) gives rise …

The majority of animal phyla have species that can regenerate. Comparing regeneration
across animals can reconstruct the molecular and cellular evolutionary history of this …

INTRODUCTION Understanding the differentiation of stem cells into the vast amount of cell
types that form the human body is a central problem of basic and medical science. The …

Alternative splicing (AS) of precursor RNAs is responsible for greatly expanding the
regulatory and functional capacity of eukaryotic genomes. Of the different classes of AS …

Background Alternative splicing (AS) is a widespread regulatory mechanism in multicellular
organisms. Numerous transcriptomic and single-gene studies in plants have investigated AS …

Vertebrates have greatly elaborated the basic chordate body plan and evolved highly
distinctive genomes that have been sculpted by two whole-genome duplications. Here we …

Alternative splicing (AS) generates vast transcriptomic and proteomic complexity. However,
which of the myriad of detected AS events provide important biological functions is not well …

Planarians are flatworms capable of regenerating any missing body region. This capacity is
mediated by neoblasts, a proliferative cell population that contains pluripotent stem cells …

Previous investigations of the core gene regulatory circuitry that controls the pluripotency of
embryonic stem (ES) cells have largely focused on the roles of transcription, chromatin and …

Background The ability to assess gene function is essential for understanding biological
processes. Currently, RNA interference (RNAi) is the only technique available to assess …