Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?

B Liu, M Li, Z Zhou, X Guan, Y **ang - Journal of autoimmunity, 2020 - Elsevier
The emergent outbreak of coronavirus disease 2019 (COVID-19) has caused a global
pandemic. Acute respiratory distress syndrome (ARDS) and multiorgan dysfunction are …

Insights into the immuno-pathogenesis of acute respiratory distress syndrome

JJM Wong, JY Leong, JH Lee… - Annals of translational …, 2019 - pmc.ncbi.nlm.nih.gov
Acute respiratory distress syndrome (ARDS) is a clinical syndrome associated with
oxygenation failure resulting from a direct pulmonary or indirect systemic insult. It is a …

Platelet–neutrophil crosstalk in atherothrombosis

J Pircher, B Engelmann, S Massberg… - Thrombosis and …, 2019 - thieme-connect.com
Atherothrombosis is a frequent cause of cardiovascular mortality. It is mostly triggered by
plaque rupture and exposure of the thrombogenic subendothelial matrix, which initiates …

Effect of aspirin on deaths associated with sepsis in healthy older people (ANTISEPSIS): a randomised, double-blind, placebo-controlled primary prevention trial

DP Eisen, K Leder, RL Woods, JE Lockery… - The Lancet …, 2021 - thelancet.com
Background Sepsis is a serious global health issue and a major cause of death and
disability. The availability of a simple, community-based preventive strategy could …

RvD1 ameliorates LPS-induced acute lung injury via the suppression of neutrophil infiltration by reducing CXCL2 expression and release from resident alveolar …

HW Zhang, Q Wang, HX Mei, SX Zheng, AM Ali… - International …, 2019 - Elsevier
Acute lung injury (ALI) and/or acute respiratory distress syndrome (ARDS) are life-
threatening critical syndromes characterized by the infiltration of a large number of …

Neutrophil-specific Shp1 loss results in lethal pulmonary hemorrhage in mouse models of acute lung injury

SF Moussavi-Harami, SJ Cleary, M Magnen… - The Journal of clinical …, 2024 - jci.org
Acute respiratory distress syndrome (ARDS) is associated with significant morbidity and
mortality, and neutrophils are critical to its pathogenesis. Neutrophil activation is closely …

The role of G protein-coupled receptor in neutrophil dysfunction during sepsis-induced acute respiratory distress syndrome

Y Wang, C Zhu, P Li, Q Liu, H Li, C Yu, X Deng… - Frontiers in …, 2023 - frontiersin.org
Sepsis is defined as a life-threatening dysfunction due to a dysregulated host response to
infection. It is a common and complex syndrome and is the leading cause of death in …

Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse

S Lax, J Rayes, S Wichaiyo… - … of Physiology-Lung …, 2017 - journals.physiology.org
There is no therapeutic intervention proven to prevent acute respiratory distress syndrome
(ARDS). Novel mechanistic insights into the pathophysiology of ARDS are therefore …

Emerging drugs for treating the acute respiratory distress syndrome

TD Shaw, DF McAuley, CM O'Kane - Expert opinion on emerging …, 2019 - Taylor & Francis
Introduction: The acute respiratory distress syndrome (ARDS) is a common and catastrophic
condition, with a high mortality rate and economic burden on society. Despite 50 years of …

Pulmonary drug delivery devices and nanosystems as potential treatment strategies for acute respiratory distress syndrome (ARDS)

CT Dhege, P Kumar, YE Choonara - International Journal of Pharmaceutics, 2024 - Elsevier
Despite advances in drug delivery technologies, treating acute respiratory distress
syndrome (ARDS) is challenging due to pathophysiological barriers such as lung injury …