During the last decades, high-throughput assessment of gene expression in patient tissues
using microarray technology or RNA-Seq took center stage in clinical research. Insights into …

Most complex diseases involve genetic and environmental risk factors, engage multiple cells
and tissues, and follow a polygenic or omnigenic model depicting numerous genes …

The Mergeomics web server is a flexible online tool for multi-omics data integration to derive
biological pathways, networks, and key drivers important to disease pathogenesis and is …

Single-cell multi-omics technologies are rapidly evolving, prompting both methodological
advances and biological discoveries at an unprecedented speed. Gene regulatory network …

Psoriasis is a common non-communicable chronic immune-mediated skin disease, affecting
approximately 125 million people in the world. Its pathogenesis results from a combination …

The knowledge about the effects of environmental temperature on human epigenome is a
potential key to understand the health impacts of temperature and to guide acclimation …

Psoriasis and atopic dermatitis (AD) are multifactorial and heterogeneous inflammatory skin
diseases, while years of research have yielded no cure, and the costs associated with caring …

In recent years, genome-wide association studies (GWAS) have been instrumental in
unraveling the genetic architecture of complex diseases, including psoriasis. The application …

Non-alcoholic fatty liver disease (NAFLD) is a progressive condition of the liver
encompassing a range of pathologies including steatosis, non-alcoholic steatohepatitis …

Mouse models have been used extensively to study human coronary artery disease (CAD)
or atherosclerosis and to test therapeutic targets. However, whether mouse and human …