When pluripotent cells are exposed to a uniform culture environment they routinely display
heterogeneous gene expression. Aspects of this heterogeneity, such as Nanog expression …

Telomeres are specialized structures that evolved to protect the end of linear chromosomes
from the action of the cell DNA damage machinery. They are composed of tandem arrays of …

Mouse embryonic stem cells (ESCs) sporadically express preimplantation two-cell-stage
(2C) transcripts, including MERVL endogenous retrovirus and Zscan4 cluster genes. Such …

Naive epiblast and embryonic stem cells (ESCs) give rise to all cells of adults. Such
developmental plasticity is associated with genome hypomethylation. Here, we show that …

Erk signaling is indispensable for the self-renewal and differentiation of mouse embryonic
stem cells (ESCs), as well as telomere homeostasis. But how Erk regulates these biological …

As they proliferate, living cells undergo transitions between specific molecularly and
developmentally distinct states. Despite the functional centrality of these transitions in …

CTCF is crucial for chromatin structure and transcription regulation in early embryonic
development. However, the kinetics of CTCF chromatin occupation in preimplantation …

Embryonic stem cells (ESCs), somatic cell nuclear transfer ESCs, and induced pluripotent
stem cells (iPSCs) represent the most studied group of PSCs. Unlimited self-renewal without …

Proper telomere length is essential for indefinite self-renewal of embryonic stem (ES) cells
and cancer cells. Telomerase-deficient late generation mouse ES cells and human ALT …

Early blastomeres of mouse preimplantation embryos exhibit bi-potential cell fate, capable of
generating both embryonic and extra-embryonic lineages in blastocysts. Here we identify …