Toward defining deep brain stimulation targets in MNI space: a subcortical atlas based on multimodal MRI, histology and structural connectivity

S Ewert, P Plettig, N Li, MM Chakravarty, DL Collins… - Neuroimage, 2018 - Elsevier
Three-dimensional atlases of subcortical brain structures are valuable tools to reference
anatomy in neuroscience and neurology. For instance, they can be used to study the …

Mechanisms of deep brain stimulation

TM Herrington, JJ Cheng… - Journal of …, 2016 - journals.physiology.org
Deep brain stimulation (DBS) is widely used for the treatment of movement disorders
including Parkinson's disease, essential tremor, and dystonia and, to a lesser extent, certain …

Lead-DBS v2: Towards a comprehensive pipeline for deep brain stimulation imaging

A Horn, N Li, TA Dembek, A Kappel, C Boulay, S Ewert… - Neuroimage, 2019 - Elsevier
Deep brain stimulation (DBS) is a highly efficacious treatment option for movement disorders
and a growing number of other indications are investigated in clinical trials. To ensure …

[HTML][HTML] Opportunities of connectomic neuromodulation

A Horn, MD Fox - Neuroimage, 2020 - Elsevier
The process of altering neural activity–neuromodulation–has long been used to treat
patients with brain disorders and answer scientific questions. Deep brain stimulation in …

Insights and opportunities for deep brain stimulation as a brain circuit intervention

WJ Neumann, A Horn, AA Kühn - Trends in Neurosciences, 2023 - cell.com
Deep brain stimulation (DBS) is an effective treatment and has provided unique insights into
the dynamic circuit architecture of brain disorders. This Review illustrates our current …

Toward an electrophysiological “sweet spot” for deep brain stimulation in the subthalamic nucleus

A Horn, WJ Neumann, K Degen… - Human brain …, 2017 - Wiley Online Library
Enhanced beta‐band activity recorded in patients suffering from Parkinson's Disease (PD)
has been described as a potential physiomarker for disease severity. Beta power is …

Optimal deep brain stimulation sites and networks for cervical vs. generalized dystonia

A Horn, MM Reich, S Ewert, N Li… - Proceedings of the …, 2022 - National Acad Sciences
Dystonia is a debilitating disease with few treatment options. One effective option is deep
brain stimulation (DBS) to the internal pallidum. While cervical and generalized forms of …

The cortico-basal ganglia-cerebellar network: past, present and future perspectives

D Milardi, A Quartarone, A Bramanti… - Frontiers in systems …, 2019 - frontiersin.org
Much of our present understanding of the function and operation of the basal ganglia rests
on models of anatomical connectivity derived from tract-tracing approaches in rodents and …

[HTML][HTML] Toward electrophysiology-based intelligent adaptive deep brain stimulation for movement disorders

WJ Neumann, RS Turner, B Blankertz, T Mitchell… - …, 2019 - Elsevier
Deep brain stimulation (DBS) represents one of the major clinical breakthroughs in the age
of translational neuroscience. In 1987, Benabid and colleagues demonstrated that high …

[HTML][HTML] Beta bursts during continuous movements accompany the velocity decrement in Parkinson's disease patients

R Lofredi, H Tan, WJ Neumann, CH Yeh… - Neurobiology of …, 2019 - Elsevier
Bradykinesia is reported to correlate with subthalamic beta power (13–35 Hz) recorded at
rest in Parkinson's disease (PD). Pilot studies suggest adaptive deep brain stimulation …