Gliomas are the most common primary brain tumors. Particularly in adult patients, the vast
majority of gliomas belongs to the heterogeneous group of diffuse gliomas, ie. glial tumors …

Brain cancers and neurodegenerative diseases are on the rise, treatments for central
nervous system (CNS) diseases remain limited. Despite the significant advancement in drug …

Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated
fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid …

The proliferative and invasive nature of malignant cancers drives lethality. In glioblastoma,
these two processes are presumed mutually exclusive and hence termed “go or grow.” We …

The complexity of the nervous system structure and function, and its slow regeneration rate,
makes it more difficult to treat compared to other tissues in the human body when an injury …

Purpose Glioblastoma (GBM) is a devastating disease. With the current treatment of surgery
followed by chemoradiation, outcomes remain poor, with median survival of only 15 months …

Glioblastoma (GBM) is the most common primary brain tumor and carries a grave prognosis.
Despite years of research investigating potentially new therapies for GBM, the median …

Resection of brain tumors is followed by chemotherapy and radiation to ablate remaining
malignant cell populations. Targeting these populations stands to reduce tumor recurrence …

Purpose: High-grade glioma (HGG) treatment is limited by the inability of otherwise
potentially efficacious drugs to penetrate the blood–brain barrier. We evaluate the unique …

Glioma is the most common malignant tumor of the brain. The postoperative recurrence rate
was high, and the 2-year survival rate only increased by 20%–25%. The reason is the blood …