Structural insights into the functional roles of 14-3-3 proteins
V Obsilova, T Obsil - Frontiers in molecular biosciences, 2022 - frontiersin.org
Signal transduction cascades efficiently transmit chemical and/or physical signals from the
extracellular environment to intracellular compartments, thereby eliciting an appropriate …
extracellular environment to intracellular compartments, thereby eliciting an appropriate …
[HTML][HTML] Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects
Members of the HECT family of E3 ubiquitin-protein ligases are characterized by a C-
terminal HECT domain that catalyzes the covalent attachment of ubiquitin to substrate …
terminal HECT domain that catalyzes the covalent attachment of ubiquitin to substrate …
Endocytosis and signaling: cell logistics shape the eukaryotic cell plan
S Sigismund, S Confalonieri, A Ciliberto… - Physiological …, 2012 - journals.physiology.org
Our understanding of endocytosis has evolved remarkably in little more than a decade. This
is the result not only of advances in our knowledge of its molecular and biological workings …
is the result not only of advances in our knowledge of its molecular and biological workings …
(Patho) physiological significance of the serum-and glucocorticoid-inducible kinase isoforms
F Lang, C Bohmer, M Palmada… - Physiological …, 2006 - journals.physiology.org
The serum-and glucocorticoid-inducible kinase-1 (SGK1) is ubiquitously expressed and
under genomic control by cell stress (including cell shrinkage) and hormones (including …
under genomic control by cell stress (including cell shrinkage) and hormones (including …
Roles of glutamine in neurotransmission
J Albrecht, M Sidoryk-Węgrzynowicz, M Zielińska… - Neuron glia …, 2010 - cambridge.org
Glutamine (Gln) is found abundantly in the central nervous system (CNS) where it
participates in a variety of metabolic pathways. Its major role in the brain is that of a …
participates in a variety of metabolic pathways. Its major role in the brain is that of a …
Regulation of ion channels by the serum‐and glucocorticoid‐inducible kinase SGK1
F Lang, E Shumilina - The FASEB Journal, 2013 - Wiley Online Library
The ubiquitously expressed serum‐and glucocorticoid‐inducible kinase‐1 (SGK1) is
genomically regulated by cell stress (including cell shrinkage) and several hormones …
genomically regulated by cell stress (including cell shrinkage) and several hormones …
Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions
The Nedd4 (neural precursor cell-expressed developmentally downregulated gene 4) family
of ubiquitin ligases (E3s) is characterized by a distinct modular domain architecture, with …
of ubiquitin ligases (E3s) is characterized by a distinct modular domain architecture, with …
NEDD4-2 (NEDD4L): the ubiquitin ligase for multiple membrane proteins
Abstract NEDD4-2 (also known as NEDD4L, neural precursor cell expressed
developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family …
developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family …
mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation
F Hong, MD Larrea, C Doughty, DJ Kwiatkowski… - Molecular cell, 2008 - cell.com
The cell-cycle effects of mTORC1 are not fully understood. We provide evidence that mTOR-
raptor phosphorylates SGK1 to modulate p27 function. Cellular mTOR activation, by …
raptor phosphorylates SGK1 to modulate p27 function. Cellular mTOR activation, by …
The Nedd4-like family of E3 ubiquitin ligases and cancer
C Chen, LE Matesic - Cancer and Metastasis Reviews, 2007 - Springer
Accumulating evidence suggests that E3 ubiquitin ligases play important roles in cancer
development. In this article, we provide a comprehensive summary of the roles of the Nedd4 …
development. In this article, we provide a comprehensive summary of the roles of the Nedd4 …