[HTML][HTML] Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies

R Bhattacharjee, SS Das, SS Biswal, A Nath… - Critical reviews in …, 2022 - Elsevier
Purpose Cervical cancer (CC), one of the major causes of death of women throughout the
world is primarily caused due to Human Papilloma Virus (HPV) 16 and 18. The early region …

Human papillomaviruses as infectious agents in gynecological cancers. Oncogenic properties of viral proteins

DA Haręża, JR Wilczyński, E Paradowska - International journal of …, 2022 - mdpi.com
Human papillomaviruses (HPVs), which belong to the Papillomaviridae family, constitute a
group of small nonenveloped double-stranded DNA viruses. HPV has a small genome that …

Dissecting the single-cell transcriptome network of immune environment underlying cervical premalignant lesion, cervical cancer and metastatic lymph nodes

C Li, K Hua - Frontiers in immunology, 2022 - frontiersin.org
Cervical cancer (CC) is one of the most common malignancy in women worldwide. It is
characterized by a natural continuous phenomenon, that is, it is in the initial stage of HPV …

[HTML][HTML] Cervical cancer therapies: Current challenges and future perspectives

CA Burmeister, SF Khan, G Schäfer, N Mbatani… - Tumour Virus …, 2022 - Elsevier
Cervical cancer is the fourth most common female cancer worldwide and results in over 300
000 deaths globally. The causative agent of cervical cancer is persistent infection with high …

MicroRNA involvement in signaling pathways during viral infection

MG Barbu, CE Condrat, DC Thompson… - Frontiers in cell and …, 2020 - frontiersin.org
The study of miRNAs started in 1993, when Lee et al. observed their involvement in the
downregulation of a crucial protein known as LIN-14 in the nematode Caenorhabditis …

[HTML][HTML] Saliva as a potential non-invasive liquid biopsy for early and easy diagnosis/prognosis of head and neck cancer

P Kumar, S Gupta, BC Das - Translational oncology, 2024 - Elsevier
Head and neck squamous cell carcinomas (HNSCCs) are the most devastating diseases in
India and southeast Asia. It is a preventable and curable disease if detected early. Tobacco …

Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1—NFκB—IL-6 signalling axis

EL Morgan, A Macdonald - PLoS pathogens, 2019 - journals.plos.org
Persistent human papillomavirus (HPV) infection is the leading cause of cervical cancer.
Although the fundamental link between HPV infection and oncogenesis is established, the …

[HTML][HTML] Inflammation and cancer: paradoxical roles in tumorigenesis and implications in immunotherapies

X Liu, L Yin, S Shen, Y Hou - Genes & Diseases, 2023 - Elsevier
Chronic inflammation caused by persistent infections and metabolic disorders is thought to
contribute to the increased cancer risk and the accelerated cancer progression. Oppositely …

From microbiome to inflammation: the key drivers of cervical cancer

ZW Zhou, HZ Long, Y Cheng, HY Luo… - Frontiers in …, 2021 - frontiersin.org
Cervical cancer is the third leading cause of cancer-related death worldwide. Microbes and
hosts form a mutually beneficial symbiosis relationship, and various parts of the host body …

HPV E6/E7: insights into their regulatory role and mechanism in signaling pathways in HPV-associated tumor

Q Peng, L Wang, L Zuo, S Gao, X Jiang, Y Han… - Cancer gene …, 2024 - nature.com
Human papillomavirus (HPV) is a class of envelope-free double-stranded DNA virus. HPV
infection has been strongly associated with the development of many malignancies, such as …