Statin-associated side effects
Hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors or statins are well
tolerated, but associated with various statin-associated symptoms (SAS), including statin …
tolerated, but associated with various statin-associated symptoms (SAS), including statin …
Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society consensus panel statement on assessment, aetiology and …
ES Stroes, PD Thompson, A Corsini… - European heart …, 2015 - academic.oup.com
Statin-associated muscle symptoms (SAMS) are one of the principal reasons for statin non-
adherence and/or discontinuation, contributing to adverse cardiovascular outcomes. This …
adherence and/or discontinuation, contributing to adverse cardiovascular outcomes. This …
OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies
M Roth, A Obaidat, B Hagenbuch - British journal of …, 2012 - Wiley Online Library
The human organic anion and cation transporters are classified within two SLC
superfamilies. Superfamily SLCO (formerly SLC21A) consists of organic anion transporting …
superfamilies. Superfamily SLCO (formerly SLC21A) consists of organic anion transporting …
Listening to drug delivery and responses via photoacoustic imaging
Administrating pharmaceutic agents efficiently to achieve the therapeutic effect is the aim of
all drug delivery techniques. Recent drug delivery systems aim to deliver high doses of …
all drug delivery techniques. Recent drug delivery systems aim to deliver high doses of …
Negative statin-related news stories decrease statin persistence and increase myocardial infarction and cardiovascular mortality: a nationwide prospective cohort …
SF Nielsen, BG Nordestgaard - European heart journal, 2016 - academic.oup.com
Aim We tested the hypothesis that statin-related news stories, cardiovascular disease,
diabetes, statin dose, calendar year, and socio-demographic status are associated with …
diabetes, statin dose, calendar year, and socio-demographic status are associated with …
Statin-related myotoxicity: a comprehensive review of pharmacokinetic, pharmacogenomic and muscle components
RM Turner, M Pirmohamed - Journal of clinical medicine, 2019 - mdpi.com
Statins are a cornerstone in the pharmacological prevention of cardiovascular disease.
Although generally well tolerated, a small subset of patients experience statin-related …
Although generally well tolerated, a small subset of patients experience statin-related …
Multidrug resistance protein 1 (MRP1, ABCC1), a “multitasking” ATP-binding cassette (ABC) transporter
SPC Cole - Journal of Biological Chemistry, 2014 - ASBMB
The multidrug resistance protein 1 (MRP1) encoded by ABCC1 was originally discovered as
a cause of multidrug resistance in tumor cells. However, it is now clear that MRP1 serves a …
a cause of multidrug resistance in tumor cells. However, it is now clear that MRP1 serves a …
Renal drug transporters and drug interactions
Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …
Furthermore, the molecular mechanisms of tubular secretion have been progressively …
The SLCO (former SLC21) superfamily of transporters
B Hagenbuch, B Stieger - Molecular aspects of medicine, 2013 - Elsevier
The members of the organic anion transporting polypeptide superfamily (OATPs) are
classified within the SLCO solute carrier family. All functionally well characterized members …
classified within the SLCO solute carrier family. All functionally well characterized members …
Drug transporters in drug efficacy and toxicity
MK DeGorter, CQ **a, JJ Yang… - Annual review of …, 2012 - annualreviews.org
Drug transporters are now widely acknowledged as important determinants governing drug
absorption, excretion, and, in many cases, extent of drug entry into target organs. There is …
absorption, excretion, and, in many cases, extent of drug entry into target organs. There is …