[HTML][HTML] Modulating glucocorticoid receptor actions in physiology and pathology: Insights from coregulators
Glucocorticoids (GCs) are a class of steroid hormones that regulate key physiological
processes such as metabolism, immune function, and stress responses. The effects of GCs …
processes such as metabolism, immune function, and stress responses. The effects of GCs …
Therapeutic applications of ginseng natural compounds for health management
Ginseng is usually consumed as a daily food supplement to improve health and has been
shown to benefit skeletal muscle, improve glucose metabolism, and ameliorate muscle …
shown to benefit skeletal muscle, improve glucose metabolism, and ameliorate muscle …
[HTML][HTML] Identifying cancer cachexia in patients without weight loss information: machine learning approaches to address a real-world challenge
L Yin, J Cui, X Lin, N Li, Y Fan, L Zhang, J Liu… - The American Journal of …, 2022 - Elsevier
Background Diagnosing cancer cachexia relies extensively on patient-reported historic
weight, and failure to accurately recall this information can lead to severe underestimation of …
weight, and failure to accurately recall this information can lead to severe underestimation of …
A phase Ib first-in-patient study assessing the safety, tolerability, pharmacokinetics, and pharmacodynamics of ponsegromab in participants with cancer and cachexia
Purpose: Cachexia is common in patients with advanced cancer and is associated with
elevated serum growth differentiation factor 15 (GDF-15) concentrations. This first-in-patient …
elevated serum growth differentiation factor 15 (GDF-15) concentrations. This first-in-patient …
Targeting cancer cachexia: Molecular mechanisms and clinical study
Cancer cachexia is a complex systemic catabolism syndrome characterized by muscle
wasting. It affects multiple distant organs and their crosstalk with cancer constitute cancer …
wasting. It affects multiple distant organs and their crosstalk with cancer constitute cancer …
Molecular Mechanisms of Cachexia: A Review
Cachexia is a condition characterized by substantial loss of body weight resulting from the
depletion of skeletal muscle and adipose tissue. A considerable fraction of patients with …
depletion of skeletal muscle and adipose tissue. A considerable fraction of patients with …
Bone-muscle crosstalk under physiological and pathological conditions
Anatomically connected bones and muscles determine movement of the body. Forces
exerted on muscles are then turned to bones to promote osteogenesis. The crosstalk …
exerted on muscles are then turned to bones to promote osteogenesis. The crosstalk …
Exploring metabolic pathways of Anamorelin, a selective agonist of the growth hormone Secretagogue receptor, via molecular networking
In this study, we delineated the poorly characterized metabolism of anamorelin, a growth
hormone secretagogue receptor agonist, in vitro using human liver microsomes (HLM) …
hormone secretagogue receptor agonist, in vitro using human liver microsomes (HLM) …
[HTML][HTML] Therapeutic applications of ginseng for skeletal muscle-related disorder management
Skeletal muscle (SM) is the largest organ of the body and is largely responsible for the
metabolism required to maintain body functions. Furthermore, the maintenance of SM is …
metabolism required to maintain body functions. Furthermore, the maintenance of SM is …
Cucurbitacin IIb attenuates cancer cachexia induced skeletal muscle atrophy by regulating the IL‐6/STAT3/FoxO signaling pathway
Y Wang, X Sun, Q Yang, C Guo - Phytotherapy Research, 2023 - Wiley Online Library
The main features of cancer cachexia include skeletal muscle atrophy, which can
significantly reduce the quality of life of patients. Clinical treatment of cancer cachexia is …
significantly reduce the quality of life of patients. Clinical treatment of cancer cachexia is …