SCN5A gene encodes the pore-forming ion-conducting α-subunit of the cardiac sodium
channel (Nav1. 5), which is responsible for the initiation and propagation of action potentials …

There is increasing evidence regarding the prevalence of genetic cardiomyopathies, for
which arrhythmias may be the first presentation. Ventricular and atrial arrhythmias …

Voltage-gated sodium channel Na v 1.5 generates cardiac action potentials and initiates the
heartbeat. Here, we report structures of Na V 1.5 at 3.2–3.5 Å resolution. Na V 1.5 is …

The SCN5A gene encodes the alpha subunit of the main cardiac sodium channel Nav1. 5.
This channel predominates inward sodium current (INa) and plays a critical role in …

Voltage-gated sodium channels initiate action potentials in nerve and muscle, and voltage-
gated calcium channels couple depolarization of the plasma membrane to intracellular …

This review summarizes our current knowledge of human disease-relevant genetic variants
within the family of voltage gated Ca2+ channels. Ca2+ channelopathies cover a wide …

We celebrate this year the 50th anniversary of the first electrophysiological recordings of the
gating currents from voltage-dependent ion channels done in 1973. This retrospective tries …

Dilated cardiomyopathy (DCM) is a highly prevalent and genetically heterogeneous
condition that results in decreased contractility and impaired cardiac function. The FK506 …

Potassium-sensitive hypokalaemic and normokalaemic periodic paralysis are inherited
skeletal muscle diseases characterized by episodes of flaccid muscle weakness,. They are …

Dilated cardiomyopathy is a rare cardiac disease characterized by left ventricular dilatation
and systolic dysfunction leading to heart failure and sudden cardiac death. Currently …