The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …

Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …

Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …

Palmitic acid (PA) has been for long time negatively depicted for its putative detrimental
health effects, shadowing its multiple crucial physiological activities. PA is the most common …

Cannabis has been used for medicinal purposes for thousands of years. The prohibition of
cannabis in the middle of the 20th century has arrested cannabis research. In recent years …

Obesity is an important aspect of the metabolic syndrome and is often associated with
chronic inflammation. In this context, inflammation of organs participating in energy …

Peroxisome proliferator-activated receptors are expressed in many tissues, including
adipocytes, hepatocytes, muscles and endothelial cells; however, the affinity depends on the …

Lipids encompass a wide variety of molecules such as fatty acids, sterols, phospholipids,
and triglycerides. These molecules represent a highly efficient energy resource and can act …

The endocannabinoid system is currently defined as the ensemble of the two 7-
transmembrane-domain and G protein-coupled receptors for Δ 9-tetrahydrocannabinol (but …

A great need exists for the development of new medications to treat pain resulting from
various disease states and types of injury. Given that the endogenous cannabinoid (that is …