[HTML][HTML] Predicting RNA secondary structures from sequence and probing data

R Lorenz, MT Wolfinger, A Tanzer, IL Hofacker - Methods, 2016 - Elsevier
RNA secondary structures have proven essential for understanding the regulatory functions
performed by RNA such as microRNAs, bacterial small RNAs, or riboswitches. This success …

A Hitchhiker's guide to RNA–RNA structure and interaction prediction tools

FYF Tieng, MR Abdullah-Zawawi… - Briefings in …, 2024 - academic.oup.com
RNA biology has risen to prominence after a remarkable discovery of diverse functions of
noncoding RNA (ncRNA). Most untranslated transcripts often exert their regulatory functions …

Informative RNA base embedding for RNA structural alignment and clustering by deep representation learning

M Akiyama, Y Sakakibara - NAR genomics and bioinformatics, 2022 - academic.oup.com
Effective embedding is actively conducted by applying deep learning to biomolecular
information. Obtaining better embeddings enhances the quality of downstream analyses …

Sequence similarity governs generalizability of de novo deep learning models for RNA secondary structure prediction

X Qiu - PLOS Computational Biology, 2023 - journals.plos.org
Making no use of physical laws or co-evolutionary information, de novo deep learning (DL)
models for RNA secondary structure prediction have achieved far superior performances …

The identification and functional annotation of RNA structures conserved in vertebrates

SE Seemann, AH Mirza, C Hansen… - Genome …, 2017 - genome.cshlp.org
Structured elements of RNA molecules are essential in, eg, RNA stabilization, localization,
and protein interaction, and their conservation across species suggests a common …

The landscape of the non-canonical RNA-binding site of Gemin5 unveils a feedback loop counteracting the negative effect on translation

R Francisco-Velilla… - Nucleic Acids …, 2018 - academic.oup.com
Gemin5 is a predominantly cytoplasmic protein that downregulates translation, beyond
controlling snRNPs assembly. The C-terminal region harbors a non-canonical RNA-binding …

Long intergenic non-coding RNAs of human chromosome 18: focus on cancers

PV Ershov, EO Yablokov, YV Mezentsev, AS Ivanov - Biomedicines, 2024 - mdpi.com
Malignant neoplasms are characterized by high molecular heterogeneity due to multilevel
deregulation of gene expression and cellular functions. It is known that non-coding RNAs …

RNA threading with secondary structure and sequence profile

Z Du, Z Peng, J Yang - Bioinformatics, 2024 - academic.oup.com
Motivation RNA threading aims to identify remote homologies for template-based modeling
of RNA 3D structure. Existing RNA alignment methods primarily rely on secondary structure …

[PDF][PDF] Clusters of mammalian conserved RNA structures in UTRs associate with RBP binding sites

VP Gadekar, AW Munk, M Miladi… - NAR Genomics and …, 2024 - academic.oup.com
RNA secondary structures play essential roles in the formation of the tertiary structure and
function of a transcript. Recent genome-wide studies highlight significant potential for RNA …

KnotAli: informed energy minimization through the use of evolutionary information

M Gray, S Chester, H Jabbari - BMC bioinformatics, 2022 - Springer
Background Improving the prediction of structures, especially those containing pseudoknots
(structures with crossing base pairs) is an ongoing challenge. Homology-based methods …