A guide to complement biology, pathology and therapeutic opportunity
Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …
[HTML][HTML] The complement system in COVID-19: friend and foe?
Abstract Coronavirus disease 2019 (COVID-19), the disease caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in a global pandemic and a …
respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in a global pandemic and a …
Complosome—the intracellular complement system
The complement system is a recognized pillar of host defence against infection and noxious
self-derived antigens. Complement is traditionally known as a serum-effective system …
self-derived antigens. Complement is traditionally known as a serum-effective system …
New insights into the immune functions of complement
The recognition of microbial or danger-associated molecular patterns by complement
proteins initiates a cascade of events that culminates in the activation of surface complement …
proteins initiates a cascade of events that culminates in the activation of surface complement …
Novel mechanisms and functions of complement
Progress at the beginning of the 21st century transformed the perception of complement
from that of a blood-based antimicrobial system to that of a global regulator of immunity and …
from that of a blood-based antimicrobial system to that of a global regulator of immunity and …
Context-dependent roles of complement in cancer
The tumour microenvironment (TME) highly influences the growth and spread of tumours,
thus impacting the patient's clinical outcome. In this context, the complement system plays a …
thus impacting the patient's clinical outcome. In this context, the complement system plays a …
Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation
While serum-circulating complement destroys invading pathogens, intracellularly active
complement, termed the “complosome,” functions as a vital orchestrator of cell-metabolic …
complement, termed the “complosome,” functions as a vital orchestrator of cell-metabolic …
Complement system and the kidney: its role in renal diseases, kidney transplantation and renal cell carcinoma
F Lasorsa, M Rutigliano, M Milella, M Ferro… - International Journal of …, 2023 - mdpi.com
The crosstalk among the complement system, immune cells, and mediators of inflammation
provides an efficient mechanism to protect the organism against infections and support the …
provides an efficient mechanism to protect the organism against infections and support the …
Cell-autonomous regulation of complement C3 by factor H limits macrophage efferocytosis and exacerbates atherosclerosis
Complement factor H (CFH) negatively regulates consumption of complement component 3
(C3), thereby restricting complement activation. Genetic variants in CFH predispose to …
(C3), thereby restricting complement activation. Genetic variants in CFH predispose to …
Complement and the regulation of T cell responses
The complement system is an evolutionarily ancient key component of innate immunity
required for the detection and removal of invading pathogens. It was discovered more than …
required for the detection and removal of invading pathogens. It was discovered more than …