Carbohydrates are a fundamental unit playing pivotal roles in all the biological processes. It
is thus essential to develop methods for synthesizing, functionalizing, and manipulating …

Methods for site-selective transformations of hydroxyl groups in carbohydrate derivatives are
reviewed. The construction of oligosaccharides of defined connectivity hinges on such …

Carbohydrates, which are ubiquitously distributed throughout the three domains of life, play
significant roles in a variety of vital biological processes. Access to unique and …

Non-covalent interactions (NCIs) are a vital component of biological bond-forming events,
and have found important applications in multiple branches of chemistry. In recent years, the …

Many organisms use sugars as building blocks for more complex structures in nature such
as cellulose in plants and chitin in crustaceans. To construct these large polysaccharides …

Discussed herein is the synthesis of partially protected carbohydrates by manipulating only
one type of a protecting group for a given substrate. The first focus of this review is the …

Site-selective functionalization of hydroxyl groups in carbohydrates is one of the long-
standing challenges in chemistry. Using a pair of chiral catalysts, we now can differentiate …

Stereochemical editing strategies have recently enabled the transformation of readily
accessible substrates into rare and valuable products. Typically, site selectivity is achieved …

We demonstrated that using NaOH and NaOMe in methanol for deacylation are identical,
indicating that the Zemplén condition has been misleading us for almost 90 years. The …

Direct and site‐selective O‐arylation of carbohydrates has been a challenge in synthesis.
Herein we report a method based on copper‐catalyzed O‐arylation to address this …