Importance The X chromosome has remained enigmatic in Alzheimer disease (AD), yet it
makes up 5% of the genome and carries a high proportion of genes expressed in the brain …

White matter lesions (WML) emerge as a consequence of vascular injuries in the brain.
While they are commonly observed in aging, associations have been established with …

Background Coronary artery disease is a primary cause of death around the world, with both
genetic and environmental risk factors. Although genome‐wide association studies have …

Background Age represents a significant risk factor for the development of Alzheimer's
disease (AD); however, recent research has documented an influencing role of sex in …

Alzheimer's disease (AD) is a progressive and multifactorial disease that significantly
compromises the lives of millions of people worldwide. Since its first description more than …

Social interactions have a significant impact on health in humans and animal models. Social
isolation initiates a cascade of stress-related physiological disorders and stands as a …

Sexual dimorphism in prevalence, severity and genetic susceptibility exists for most common
diseases. However, most genetic and clinical outcome studies are designed in sex …

The human X-chromosome contains hundreds of genes and has well-established impacts
on sex differences and traits. However, the X-chromosome is often excluded from many …

Background: Our previous studies indicated that anesthesia/surgery could aggravate
cognitive impairment and tau pathology in female 5XFAD transgenic (Tg) mice. However, it …

The microtubule-associated protein tau gene (Mapt) has evolved differentially across
species, influencing its protein isoform composition, aggregation properties, and …