The raison d'être of meiosis is shuffling of genetic information via Mendelian segregation
and, within individual chromosomes, by DNA crossing-over. These outcomes are enabled …

Crossing over between homologous chromosomes in meiosis is essential in most
eukaryotes to produce gametes with the correct ploidy. Meiotic crossovers are typically …

The pathological huntingtin (HTT) trinucleotide repeat underlying Huntington disease (HD)
continues to expand throughout life. Repeat length correlates both with earlier age at onset …

Centromeres strongly affect (epi) genomic architecture and meiotic recombination dynamics,
influencing the overall distribution and frequency of crossovers. Here we show how …

Meiosis is essential for evolution and genetic diversity in almost all sexual eukaryotic
organisms. The mechanisms of meiotic recombination, such as synapsis, have been …

Meiotic crossovers are required for the faithful segregation of homologous chromosomes
and to promote genetic diversity. However, it is unclear how crossover formation is …

Pathogenic variation in DNA mismatch repair (MMR) gene MLH1 is associated with Lynch
syndrome (LS), an autosomal dominant hereditary cancer. Of the 3798 MLH1 germline …

Functional classification of genetic variants is a key for their clinical applications in patient
care. However, abundant variant data generated by the next-generation DNA sequencing …

In most sexually reproducing organisms crossing over between chromosome homologs
during meiosis is essential to produce haploid gametes. Most crossovers that form in …

Repeat-mediated deletions (RMDs) are a type of chromosomal rearrangement between two
homologous sequences that causes loss of the sequence between the repeats, along with …