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Visible-light-mediated modification and manipulation of biomacromolecules
Chemically modified biomacromolecules─ ie, proteins, nucleic acids, glycans, and lipids─
have become crucial tools in chemical biology. They are extensively used not only to …
have become crucial tools in chemical biology. They are extensively used not only to …
Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection
Oxidative stress (OS) represents a threat to the chemical integrity of biomolecules including
lipids, proteins, and DNA. The associated molecular damage frequently results in serious …
lipids, proteins, and DNA. The associated molecular damage frequently results in serious …
Photosensitization reactions of biomolecules: definition, targets and mechanisms
Photosensitization reactions have been demonstrated to be largely responsible for the
deleterious biological effects of UV and visible radiation, as well as for the curative actions of …
deleterious biological effects of UV and visible radiation, as well as for the curative actions of …
Recent advances in the development of 1, 8-naphthalimide based DNA targeting binders, anticancer and fluorescent cellular imaging agents
S Banerjee, EB Veale, CM Phelan… - Chemical Society …, 2013 - pubs.rsc.org
The development of functional 1, 8-naphthalimide derivatives as DNA targeting, anticancer
and cellular imaging agents is a fast growing area and has resulted in several such …
and cellular imaging agents is a fast growing area and has resulted in several such …
Computational strategies for predicting free radical scavengers' protection against oxidative stress: where are we and what might follow?
Oxidative stress, which is frequently induced by an overproduction of free radicals (FR),
poses a high risk to human health. Thus, finding efficient strategies for scavenging FR is a …
poses a high risk to human health. Thus, finding efficient strategies for scavenging FR is a …
Recognition and reaction of metallointercalators with DNA
KE Erkkila, DT Odom, JK Barton - Chemical Reviews, 1999 - authors.library.caltech.edu
The design of small complexes that bind and react at specific sequences of DNA becomes
important as we begin to delineate, on a molecular level, how genetic information is …
important as we begin to delineate, on a molecular level, how genetic information is …
Mechanisms for DNA charge transport
JC Genereux, JK Barton - Chemical reviews, 2010 - ACS Publications
DNA charge transport (CT) chemistry has received considerable attention by scientific
researchers over the past 15 years since our first provocative publication on long-range CT …
researchers over the past 15 years since our first provocative publication on long-range CT …
Ruthenium metallopharmaceuticals
MJ Clarke - Coordination Chemistry Reviews, 2003 - Elsevier
The well-developed synthetic chemistry of ruthenium, particularly with ammine, amine and
imine ligands, provides for many approaches to innovative new metallopharmaceuticals …
imine ligands, provides for many approaches to innovative new metallopharmaceuticals …
Oxidative DNA damage through long-range electron transfer
DB Hall, RE Holmlin, JK Barton - Nature, 1996 - nature.com
THE possibility has been considered for almost forty years that the DNA double helix, which
contains a π-stacked array of heterocyclic base pairs, could be a suitable medium for the …
contains a π-stacked array of heterocyclic base pairs, could be a suitable medium for the …
Interplay of guanine oxidation and G-quadruplex folding in gene promoters
Living in an oxygen atmosphere demands an ability to thrive in the presence of reactive
oxygen species (ROS). Aerobic organisms have successfully found solutions to the oxidative …
oxygen species (ROS). Aerobic organisms have successfully found solutions to the oxidative …