Visible-light-mediated modification and manipulation of biomacromolecules

VM Lechner, M Nappi, PJ Deneny, S Folliet… - Chemical …, 2021 - ACS Publications
Chemically modified biomacromolecules─ ie, proteins, nucleic acids, glycans, and lipids─
have become crucial tools in chemical biology. They are extensively used not only to …

Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection

A Galano, RJ Reiter - Journal of Pineal Research, 2018 - Wiley Online Library
Oxidative stress (OS) represents a threat to the chemical integrity of biomolecules including
lipids, proteins, and DNA. The associated molecular damage frequently results in serious …

Photosensitization reactions of biomolecules: definition, targets and mechanisms

MS Baptista, J Cadet, A Greer… - Photochemistry and …, 2021 - Wiley Online Library
Photosensitization reactions have been demonstrated to be largely responsible for the
deleterious biological effects of UV and visible radiation, as well as for the curative actions of …

Recent advances in the development of 1, 8-naphthalimide based DNA targeting binders, anticancer and fluorescent cellular imaging agents

S Banerjee, EB Veale, CM Phelan… - Chemical Society …, 2013 - pubs.rsc.org
The development of functional 1, 8-naphthalimide derivatives as DNA targeting, anticancer
and cellular imaging agents is a fast growing area and has resulted in several such …

Computational strategies for predicting free radical scavengers' protection against oxidative stress: where are we and what might follow?

A Galano, J Raúl Alvarez‐Idaboy - International Journal of …, 2019 - Wiley Online Library
Oxidative stress, which is frequently induced by an overproduction of free radicals (FR),
poses a high risk to human health. Thus, finding efficient strategies for scavenging FR is a …

Recognition and reaction of metallointercalators with DNA

KE Erkkila, DT Odom, JK Barton - Chemical Reviews, 1999 - authors.library.caltech.edu
The design of small complexes that bind and react at specific sequences of DNA becomes
important as we begin to delineate, on a molecular level, how genetic information is …

Mechanisms for DNA charge transport

JC Genereux, JK Barton - Chemical reviews, 2010 - ACS Publications
DNA charge transport (CT) chemistry has received considerable attention by scientific
researchers over the past 15 years since our first provocative publication on long-range CT …

Ruthenium metallopharmaceuticals

MJ Clarke - Coordination Chemistry Reviews, 2003 - Elsevier
The well-developed synthetic chemistry of ruthenium, particularly with ammine, amine and
imine ligands, provides for many approaches to innovative new metallopharmaceuticals …

Oxidative DNA damage through long-range electron transfer

DB Hall, RE Holmlin, JK Barton - Nature, 1996 - nature.com
THE possibility has been considered for almost forty years that the DNA double helix, which
contains a π-stacked array of heterocyclic base pairs, could be a suitable medium for the …

Interplay of guanine oxidation and G-quadruplex folding in gene promoters

AM Fleming, CJ Burrows - Journal of the American Chemical …, 2019 - ACS Publications
Living in an oxygen atmosphere demands an ability to thrive in the presence of reactive
oxygen species (ROS). Aerobic organisms have successfully found solutions to the oxidative …