Differential gene expression mechanisms ensure cellular differentiation and plasticity to
shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential …

Endometrial cancer is the most common gynecological cancer in the developed world, and it
is one of the few cancer types that is becoming more prevalent and leading to more deaths …

Cells must tightly regulate their gene expression programs and yet rapidly respond to acute
biochemical and biophysical cues within their environment. This information is transmitted to …

Nuclear receptor crosstalk can be defined as the interplay between different nuclear
receptors or between their overlap** signalling pathways. A subset of nuclear receptors …

The estrogen receptor (ER), glucocorticoid receptor (GR), and forkhead box protein 1
(FoxA1) are significant factors in breast cancer progression. FoxA1 has been implicated in …

The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

Estrogen receptor α (ER) is the major driver of∼ 75% of breast cancers, and multiple ER
targeting drugs are routinely used clinically to treat patients with ER+ breast cancer …

Despite the widespread use of glucocorticoids (GCs), their anti-inflammatory effects are not
understood mechanistically. Numerous investigations have examined the effects of …

Most breast cancers are driven by oestrogen receptor-α. Anti-oestrogenic drugs are the
standard treatment for these breast cancers; however, treatment resistance is common …

Pioneer transcription factors are able to bind a partially exposed motif on the surface of a
nucleosome, enabling the proteins to target sites in silent regions of chromatin that have …