Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of
differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under …

TL1A, also called TNFSF15, is a member of tumor necrosis factor family. It is expressed in
different immune cell, such as monocyte, macrophage, dendritic cell, T cell and non-immune …

Premature senescence of bone marrow-derived mesenchymal stem cells (BMSC) remains a
major concern for their application clinically. Hedgehog signaling has been reported to …

Hedgehog (Hh) signaling pathway is an evolutionarily conserved signal transduction
pathway that plays an important regulatory role during embryonic development, cell …

Abstract The Hedgehog (Hh) family is a prototypical morphogen involved in embryonic
patterning, multi-lineage differentiation, self-renewal, morphogenesis, and regeneration …

Background Synovial inflammation plays a major role in the pathogenesis of osteoarthritis
(OA). This study investigated the effect of andrographolide (Andro) on synovial inflammation …

Rheumatoid arthritis (RA) is the major autoimmune destructive disease of joints with a
complicated pathogenesis. The contribution of tumor necrosis factor‐like ligand 1A (TL1A) in …

Articular cartilage damage with subsequent impairment of joint function is a common feature
of articular diseases, in particular, rheumatoid arthritis and osteoarthritis. While articular …

Macrophages are the master regulator of the dynamic fibrogenesis–fibrosis resolution
paradigm. TNF‐like ligand 1 aberrance (TL1A) was found to be able to induce intestinal …

The quality control (QC) of pharmaceutical-grade cell-therapy products, such as
mesenchymal stem cells (MSCs), is challenging. Attempts to develop such products have …