Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions
C Qin, S Yang, YH Chu, H Zhang, XW Pang… - Signal transduction and …, 2022 - nature.com
Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces
severe neural injuries, and is one of the leading causes of death and disability worldwide …
severe neural injuries, and is one of the leading causes of death and disability worldwide …
The Beclin 1 network regulates autophagy and apoptosis
Beclin 1, the mammalian orthologue of yeast Atg6, has a central role in autophagy, a
process of programmed cell survival, which is increased during periods of cell stress and …
process of programmed cell survival, which is increased during periods of cell stress and …
[HTML][HTML] Excitotoxicity and stroke: identifying novel targets for neuroprotection
Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …
ERK: a double-edged sword in cancer. ERK-dependent apoptosis as a potential therapeutic strategy for cancer
The RAF/MEK/ERK signaling pathway regulates diverse cellular processes as exemplified
by cell proliferation, differentiation, motility, and survival. Activation of ERK1/2 generally …
by cell proliferation, differentiation, motility, and survival. Activation of ERK1/2 generally …
RAF-MEK-ERK pathway in cancer evolution and treatment
Abstract The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
ERK and cell death: mechanisms of ERK‐induced cell death–apoptosis, autophagy and senescence
S Cagnol, JC Chambard - The FEBS journal, 2010 - Wiley Online Library
The Ras/Raf/extracellular signal‐regulated kinase (ERK) signaling pathway plays a crucial
role in almost all cell functions and therefore requires exquisite control of its spatiotemporal …
role in almost all cell functions and therefore requires exquisite control of its spatiotemporal …
The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions
S Yoon, R Seger - Growth factors, 2006 - Taylor & Francis
The extracellular signal-regulated kinase (ERK) cascade is a central pathway that transmits
signals from many extracellular agents to regulate cellular processes such as proliferation …
signals from many extracellular agents to regulate cellular processes such as proliferation …
[HTML][HTML] Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke
Z Shen, M **ang, C Chen, F Ding, Y Wang… - Biomedicine & …, 2022 - Elsevier
Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic
stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most …
stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most …
Life and death partners: apoptosis, autophagy and the cross-talk between them
A Eisenberg-Lerner, S Bialik, HU Simon… - Cell Death & …, 2009 - nature.com
It is not surprising that the demise of a cell is a complex well-controlled process. Apoptosis,
the first genetically programmed death process identified, has been extensively studied and …
the first genetically programmed death process identified, has been extensively studied and …
How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?
Y Mebratu, Y Tesfaigzi - Cell cycle, 2009 - Taylor & Francis
Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) are members of the mitogen-
activated protein kinase super family that can mediate cell proliferation and apoptosis. The …
activated protein kinase super family that can mediate cell proliferation and apoptosis. The …